Host-Microbial Mutualism in Health and Disease
Gastroenterologie (UVCM) am Inselspital Bern
Full publication list
Mucosal Immunology of Host-microbial Mutualism
- Congratulations to Dr. Anna Wenning for receiving the MD-PhD fellowship from SNF
Latest Science paper in the news:
April 17th 2016: The Scientis: http://www.the-scientist.com/?articles.view/articleNo/45614/title/Mother-s-Microbiome-Shapes-Offspring-s-Immunity/ (PDF)
April 17th 2016: QZ: http://qz.com/641179/bacteria-in-your-moms-gut-influenced-the-way-you-fight-off-infections-today/ (PDF)
April 17th 2016: 24 heures: http://www.24heures.ch/savoirs/sante/bebes-renforces-grce-microbes-mere/story/28441054 (PDF)
April 17th 2016: Sciencedaily: https://www.sciencedaily.com/releases/2016/03/160317150002.htm#.VusjG8N92xE.facebook (PDF)
April 17th 2016: 20min/FR: http://www.20min.ch/ro/news/science/story/Bebes-renforces-gr-ce-aux-microbes-de-leur-mere-20207772 (PDF)
April 17th 2016: 20min/DE: (PDF)
April 17th 2016: Quo: http://www.quo.es/ciencia/lo-que-science-te-contara-manana5 (PDF)
April 17th 2016 Microbiomedigest: http://www.microbiomedigest.com/?p=4315 (PDF)
April 18th 2016: Spektrum: http://www.spektrum.de/news/muetterliche-starthilfe-fuers-immunsystem/1404675 (PDF)
Comments Science paper:
April 19th 2016: Cell Host & Microbes by Seth Rakoff-Nahoum " Another Reason to Thank Mom: Gestational Effects of Microbiota Merabolites " (pdf)
April 2016: Nature by Mihir Pendse and Lora V. Hooper "Mum's microbes boost baby's immunity" (pdf)
The main focus of gastroenterology research is in the mucosal immunology of how humans and other mammals co-exist with enormous numbers of microbes in the lower intestine (Macpherson, McCoy, Geuking). The microbes that we carry around outnumber our own cells by about 10-fold, and collectively they have about 100-fold more genes than we do. These microbes normally do not cause disease in healthy people, but they are an essential part of our bodies, helping us digest food, providing vitamins, breaking down poisonous chemicals and protecting the intestinal lining from invasion of pathogenic bacteria, which do cause disease. Our research deals with the way in which the body adapts to accept these microbes in the intestine, and how the combination of microbes helps ensure health. Many conditions, including inflammatory bowel disease (Crohn’s disease and ulcerative colitis), forms of arthritis, allergy, diabetes, liver disease and obesity are associated with alterations in the microbiota or defects in how our bodies adapt to their presence: our goal is to provide a fundamental understanding of these events to be able to provide new treatments for patients with these conditions (Wiest).
We also have programs that investigate the motility of the intestines in health and disease (Tutuian), the genetic and immune predisposition to Crohn’s disease and ulcerative colitis (Macpherson, Juillerat) and in novel treatments for inflammatory bowel disease (Seibold, Juillerat).
Picture: Illustration of the intestinal mucus layer thickness along the intestine.