Journal Club 2017



Monday, Sep. 25th, 2017 - Bahti Yilmaz

Sci Transl Med. 2017 Mar 1;9(379). pii: eaaf6397. doi: 10.1126/scitranslmed.aaf6397.
Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice.
De Palma G, Lynch MD, Lu J, Dang VT, Deng Y, Jury J, Umeh G, Miranda PM, Pigrau Pastor M, Sidani S, Pinto-Sanchez MI, Philip V, McLean PG, Hagelsieb MG, Surette MG, Bergonzelli GE, Verdu EF, Britz-McKibbin P, Neufeld JD, Collins SM, Bercik P.

PubMed Link

Immunity. 2017 Jul 18;47(1):118-134.e8. doi: 10.1016/j.immuni.2017.06.013. Epub 2017 Jul 11.
Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals.
Magri G, Comerma L, Pybus M, Sintes J, Lligé D, Segura-Garzón D, Bascones S, Yeste A, Grasset EK, Gutzeit C, Uzzan M, Ramanujam M, van Zelm MC, Albero-González R, Vazquez I, Iglesias M, Serrano S, Márquez L, Mercade E, Mehandru S, Cerutti A.

PubMed Link


Monday, Sep. 22nd, 2017 - Catherine Mooser

Nature. 2017 Sep 28;549(7673):528-532. doi: 10.1038/nature23910. Epub 2017 Sep 13.
Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring.
Kim S, Kim H, Yim YS, Ha S, Atarashi K, Tan TG, Longman RS, Honda K, Littman DR, Choi GB, Huh JR.

PubMed Link

Science. 2017 Sep 1;357(6354):912-916. doi: 10.1126/science.aan0677.
The intestinal microbiota regulates body composition through NFIL3 and the circadian clock.
Wang Y, Kuang Z, Yu X, Ruhn KA, Kubo M, Hooper LV.

PubMed Link


Monday, Sep. 4th, 2017 - Olivier

J Immunol. 2017 Aug 15;199(4):1362-1371. doi: 10.4049/jimmunol.1601527. Epub 2017 Jul 3.
Mesenchymal Cell-Specific MyD88 Signaling Promotes Systemic Dissemination of Salmonella Typhimurium via Inflammatory Monocytes.
Kim D, Seo SU, Zeng MY, Kim WU, Kamada N, Inohara N, Núñez G.

PubMed Link

Front Immunol. 2017 Aug 2;8:889. doi: 10.3389/fimmu.2017.00889. eCollection 2017.
Interleukin-10 Production by T and B Cells Is a Key Factor to Promote Systemic Salmonella enterica Serovar Typhimurium Infection in Mice.
Salazar GA, Peñaloza HF, Pardo-Roa C, Schultz BM, Muñoz-Durango N, Gómez RS, Salazar FJ, Pizarro DP, Riedel CA, González PA, Alvarez-Lobos M, Kalergis AM, Bueno SM.

PubMed Link


Monday, Aug. 10th, 2017 - Mercedes Gomez

J Exp Med. 2017 Jan;214(1):197-208. doi: 10.1084/jem.20160789. Epub 2016 Dec 23.
The aryl hydrocarbon receptor controls cell-fate decisions in B cells.
Vaidyanathan B, Chaudhry A, Yewdell WT, Angeletti D, Yen WF, Wheatley AK, Bradfield CA, McDermott AB, Yewdell JW, Rudensky AY, Chaudhuri J.

PubMed Link

Science. 2017 Aug 25;357(6353):806-810. doi: 10.1126/science.aah5825. Epub 2017 Aug 3.
Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+ T cells.
Cervantes-Barragan L, Chai JN, Tianero MD, Di Luccia B, Ahern PP, Merriman J, Cortez VS, Caparon MG, Donia MS, Gilfillan S, Cella M, Gordon JI, Hsieh CS, Colonna M.

PubMed Link


Friday, July. 7th, 2017 - Julien

Nature. 2017 Jul 6;547(7661):94-98. doi: 10.1038/nature22976. Epub 2017 Jun 21.
Identifying specificity groups in the T cell receptor repertoire.
Glanville J, Huang H, Nau A, Hatton O, Wagar LE, Rubelt F, Ji X, Han A, Krams SM, Pettus C, Haas N, Arlehamn CSL, Sette A, Boyd SD, Scriba TJ, Martinez OM, Davis MM.

PubMed Link

Nat Commun. 2017 Jun 6;8:15393. doi: 10.1038/ncomms15393.
Global metabolic interaction network of the human gut microbiota for context-specific community-scale analysis.
Sung J, Kim S1, Cabatbat JJT, Jang S, Jin YS, Jung GY, Chia N, Kim PJ.

PubMed Link


Monday, June. 26th, 2017 - Olivier 

Nat Biotechnol. 2017 Jul;35(7):653-658. doi: 10.1038/nbt.3879. Epub 2017 May 29.
Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation.
Riglar DT, Giessen TW, Baym M, Kerns SJ, Niederhuber MJ, Bronson RT, Kotula JW, Gerber GK, Way JC, Silver PA.

PubMed Link

Nat Immunol. 2017 May;18(5):552-562. doi: 10.1038/ni.3713. Epub 2017 Mar 27.
Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes.
Mariño E, Richards JL, McLeod KH, Stanley D, Yap YA, Knight J, McKenzie C, Kranich J, Oliveira AC, Rossello FJ, Krishnamurthy B, Nefzger CM, Macia L, Thorburn A, Baxter AG, Morahan G, Wong LH, Polo JM, Moore RJ, Lockett TJ, Clarke JM, Topping DL, Harrison LC, Mackay CR.

PubMed Link


Friday, June. 2nd, 2017 - Hai Li

Cell. 2017 Apr 20;169(3):547-558.e15. doi: 10.1016/j.cell.2017.03.045.
Engineered Regulatory Systems Modulate Gene Expression of Human Commensals in the Gut.
Lim B, Zimmermann M, Barry NA, Goodman AL.

PubMed Link

Nat Immunol. 2017 May;18(5):552-562. doi: 10.1038/ni.3713. Epub 2017 Mar 27.
Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes.
Mariño E, Richards JL, McLeod KH, Stanley D, Yap YA, Knight J, McKenzie C, Kranich J, Oliveira AC, Rossello FJ, Krishnamurthy B, Nefzger CM, Macia L, Thorburn A, Baxter AG, Morahan G, Wong LH, Polo JM, Moore RJ, Lockett TJ, Clarke JM, Topping DL, Harrison LC, Mackay CR.

PubMed Link


Friday, May. 19th, 2017 - Jakob

Nat Med. 2017 May;23(5):579-589. doi: 10.1038/nm.4307. Epub 2017 Apr 3.
Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.
West NR, Hegazy AN, Owens BMJ, Bullers SJ, Linggi B, Buonocore S, Coccia M, Görtz D, This S, Stockenhuber K, Pott J, Friedrich M, Ryzhakov G, Baribaud F, Brodmerkel C, Cieluch C, Rahman N, Müller-Newen G, Owens RJ, Kühl AA, Maloy KJ, Plevy SE; Oxford IBD Cohort Investigators, Keshav S, Travis SPL, Powrie F.

PubMed Link

Cell Host Microbe. 2017 May 10;21(5):592-602.e4. doi: 10.1016/j.chom.2017.04.002.
Cooperating Commensals Restore Colonization Resistance to Vancomycin-Resistant Enterococcus faecium.
Caballero S, Kim S, Carter RA, Leiner IM, Sušac B, Miller L, Kim GJ, Ling L, Pamer EG.

PubMed Link


Friday, May. 12th, 2017 - Mercedes

Science. 2017 May 5;356(6337):513-519. doi: 10.1126/science.aal3535.
Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages.
Ip WKE, Hoshi N, Shouval DS, Snapper S, Medzhitov R.

PubMed Link

Science. 2017 May 4. pii: eaag3009. doi: 10.1126/science.aag3009. [Epub ahead of print]
Mapping the human DC lineage through the integration of high-dimensional techniques.
See P, Dutertre CA, Chen J, Günther P, McGovern N, Irac SE, Gunawan M, Beyer M, Händler K, Duan K, Sumatoh HRB, Ruffin N, Jouve M, Gea-Mallorquí E, Hennekam RCM, Lim , Yip CC, Wen M, Malleret B, Low I, Shadan NB, Fen CFS, Tay A, Lum J, Zolezzi F, Larbi A, Poidinger M, Chan JKY, Chen Q, Renia L, Haniffa M, Benaroch P, Schlitzer A, Schultze JL, Newell EW, Ginhoux F.

PubMed Link


Friday, May. 5th, 2017 - Anna

Cell Host Microbe. 2017 Apr 12;21(4):467-477.e5. doi: 10.1016/j.chom.2017.03.001. Epub 2017 Mar 23.
Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.
Scharschmidt TC, Vasquez KS, Pauli ML, Leitner EG, Chu K, Truong HA, Lowe MM, Sanchez Rodriguez R, Ali N, Laszik ZG, Sonnenburg JL, Millar SE, Rosenblum MD.

PubMed Link

Nature. 2017 Feb 9;542(7640):242-245. doi: 10.1038/nature21080. Epub 2017 Feb 1.
Feedback control of AHR signalling regulates intestinal immunity.
Schiering C, Wincent E, Metidji A, Iseppon A, Li Y, Potocnik AJ, Omenetti S, Henderson CJ, Wolf CR, Nebert DW, Stockinger B.

PubMed Link


Friday, April. 28th, 2017 - Catherine

Nature. 2017 Apr 27;544(7651):498-502. doi: 10.1038/nature22058. Epub 2017 Apr 12.
High-avidity IgA protects the intestine by enchaining growing bacteria.
Moor K, Diard M, Sellin ME, Felmy B, Wotzka SY, Toska A, Bakkeren E, Arnoldini M, Bansept F, Co AD, Völler T, Minola A, Fernandez-Rodriguez B, Agatic G, Barbieri S, Piccoli L, Casiraghi C, Corti D, Lanzavecchia A, Regoes RR, Loverdo C, Stocker R, Brumley DR, Hardt WD, Slack E.

PubMed Link

Science. 2017 Apr 21;356(6335):315-319. doi: 10.1126/science.aag2029.
Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens.
Kim YG, Sakamoto K, Seo SU, Pickard JM, Gillilland MG, Pudlo NA, Hoostal M, Li X, Wang TD, Feehley T, Stefka AT, Schmidt TM, Martens EC, Fukuda S, Inohara N, Nagler CR, Núñez G.

PubMed Link


Friday, March. 24th, 2017 - Francesca

Nat Immunol. 2017 Mar;18(3):283-292. doi: 10.1038/ni.3659. Epub 2017 Jan 16.
Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation.
Dror E, Dalmas E, Meier DT, Wueest S, Thévenet J, Thienel C, Timper K, Nordmann TM, Traub S, Schulze F, Item F, Vallois D, Pattou F, Kerr-Conte J, Lavallard V, Berney T, Thorens B4, Konrad D, Böni-Schnetzler M, Donath MY.

PubMed Link

Sci Rep. 2017 Mar 8;7:43662. doi: 10.1038/srep43662.
Low-dose penicillin exposure in early life decreases Th17 and the susceptibility to DSS colitis in mice through gut microbiota modification.
Jin S, Zhao D, Cai C, Song D, Shen J, Xu A, Qiao Y, Ran Z, Zheng Q.

PubMed Link


Friday, March. 17th, 2017 - Marcel

Gut. 2017 Mar;66(3):429-437. doi: 10.1136/gutjnl-2015-310283. Epub 2016 Jan 6.
Microbiota-induced obesity requires farnesoid X receptor.
Parséus A, Sommer N, Sommer F, Caesar R, Molinaro A, Ståhlman M, Greiner TU, Perkins R, Bäckhed F.

PubMed Link

J Hepatol. 2017 Apr;66(4):724-733. doi: 10.1016/j.jhep.2016.12.005. Epub 2016 Dec 18.
The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction.
Schwabl P, Hambruch E, Seeland BA, Hayden H, Wagner M, Garnys L, Strobel B, Schubert TL, Riedl F, Mitteregger D, Burnet M, Starlinger P, Oberhuber G, Deuschle U, Rohr-Udilova N, Podesser BK, Peck-Radosavljevic M, Reiberger T, Kremoser C, Trauner M.

PubMed Link


Friday, March. 10th, 2017 - Nicolas

EMBO Mol Med. 2017 Feb 27. pii: e201606932. doi: 10.15252/emmm.201606932. [Epub ahead of print]
Faecal microbiota transplantation protects against radiation-induced toxicity.
Cui M, Xiao H, Li Y, Zhou L, Zhao S, Luo D, Zheng Q, Dong J, Zhao Y, Zhang X, Zhang J, Lu L, Wang H, Fan S.

PubMed Link

Cell. 2017 Jan 26;168(3):503-516.e12. doi: 10.1016/j.cell.2017.01.006.
Pathogen-Mediated Inhibition of Anorexia Promotes Host Survival and Transmission.
Rao S, Schieber AM, O'Connor CP, Leblanc M, Michel D, Ayres JS.

PubMed Link


Friday, Feb. 24th, 2017 - Stephanie

Nat Med. 2017 Mar;23(3):314-326. doi: 10.1038/nm.4272. Epub 2017 Jan 23.
Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery.
Chu DM, Ma J, Prince AL, Antony KM, Seferovic MD, Aagaard KM.

PubMed Link

Cell. 2017 Feb 23;168(5):928-943.e11. doi: 10.1016/j.cell.2017.01.022. Epub 2017 Feb 16.
Mining the Human Gut Microbiota for Immunomodulatory Organisms.
Geva-Zatorsky N, Sefik E, Kua L, Pasman L, Tan TG, Ortiz-Lopez A, Yanortsang TB, Yang L, Jupp R, Mathis D, Benoist C, Kasper DL.

PubMed Link


Friday, Feb. 17th, 2017 - Julien

Nat Microbiol. 2017 Feb 13;2:17004. doi: 10.1038/nmicrobiol.2017.4.
Dynamics of the human gut microbiome in inflammatory bowel disease.
Halfvarson J, Brislawn CJ, Lamendella R, Vázquez-Baeza Y, Walters WA, Bramer LM, D'Amato M, Bonfiglio F, McDonald D, Gonzalez A, McClure EE, Dunklebarger MF, Knight R, Jansson JK.

PubMed Link

Cell Host Microbe. 2017 Feb 8;21(2):208-219. doi: 10.1016/j.chom.2017.01.005.
Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis.
Hughes ER, Winter MG, Duerkop BA, Spiga L, Furtado de Carvalho T, Zhu W, Gillis CC, Büttner L, Smoot MP, Behrendt CL, Cherry S, Santos RL, Hooper LV, Winter SE.

PubMed Link


Friday, Feb. 10th, 2017 - Bahti

Cell. 2016 Nov 17;167(5):1339-1353.e21. doi: 10.1016/j.cell.2016.10.043.
A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility.
Desai MS, Seekatz AM, Koropatkin NM, Kamada N, Hickey CA, Wolter M, Pudlo NA, Kitamoto S, Terrapon N, Muller A, Young VB, Henrissat B, Wilmes P, Stappenbeck TS, Núñez G, Martens EC.

PubMed Link

Cell Host Microbe. 2017 Jan 11;21(1):84-96. doi: 10.1016/j.chom.2016.12.006. Epub 2016 Dec 29.
Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions.
Griffin NW, Ahern PP, Cheng J, Heath AC, Ilkayeva O, Newgard CB, Fontana L, Gordon JI.

PubMed Link

Monday, Jan. 9th, 2017 - Hai Li 

Cell. 2016 Dec 1;167(6):1469-1480.e12. doi: 10.1016/j.cell.2016.11.018.
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease.
Sampson TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, Challis C, Schretter CE, Rocha S, Gradinaru V, Chesselet MF, Keshavarzian A, Shannon KM, Krajmalnik-Brown R, Wittung-Stafshede P, Knight R, Mazmanian SK.

PubMed Link

Nature. 2016 Nov 24. doi: 10.1038/nature20796. [Epub ahead of print]
Persistent microbiome alterations modulate the rate of post-dieting weight regain.
Thaiss CA, Itav S, Rothschild D, Meijer M, Levy M, Moresi C, Dohnalová L, Braverman S, Rozin S, Malitsky S, Dori-Bachash M, Kuperman Y, Biton I, Gertler A, Harmelin A, Shapiro H, Halpern Z, Aharoni A, Segal E, Elinav E.

PubMed Link


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