Publications



2017

Cell. 2017 Oct 19;171(3):655-667.e17. doi: 10.1016/j.cell.2017.09.022.
A Gut Microbial Mimic that Hijacks Diabetogenic Autoreactivity to Suppress Colitis.
Nanjundappa RH, Ronchi F, Wang JG, Clemente-Casares X, Yamanouchi J, Umeshappa CS, Yang Y, Blanco J, Bassolas-Molina H, Salas A, Khan H, Slattery MR, Wyss M, Mooser C, Macpherson AJ, Sycuro L, Serra R, McKay C, McCoy KD, Santamaria P.
PubMed - Fulltext

J Immunol. 2017 Oct 1;199(7):2570-2584. doi: 10.4049/jimmunol.1700350. Epub 2017 Sep 1.
The Stimulation of Macrophages with TLR Ligands Supports Increased IL-19 Expression in Inflammatory Bowel Disease Patients and in Colitis Models.
Steinert A, Linas I, Kaya B, Ibrahim M, Schlitzer A, Hruz P, Radulovic K, Terracciano L, Macpherson AJ, Niess JH.
PubMed - Fulltext

Nat Rev Immunol. 2017 Aug;17(8):508-517. doi: 10.1038/nri.2017.58. Epub 2017 Jun 12. Review.
How nutrition and the maternal microbiota shape the neonatal immune system. 
Andrew J. Macpherson, Mercedes Gomez de Agüero and Stephanie C. Ganal-Vonarburg
PubMed - Fulltext

Curr Protoc Immunol. 2017 Apr 3;117:23.1.1-23.1.13. doi: 10.1002/cpim.25.
Gut Microbiome Standardization in Control and Experimental Mice.
McCoy KD, Geuking MB, Ronchi F.
PubMed - Fulltext

Hepatology. 2017 Mar 30. doi: 10.1002/hep.29182. [Epub ahead of print]
POLYPHENIC TRAIT PROMOTES LIVER CANCER IN A MODEL OF EPIGENETIC INSTABILITY
Marco Cassano, Sandra Offner, Evarist Planet, Alessandra Piersigilli, Suk Min Jang, Hugues Henry, Markus Geuking, Catherine Mooser, Kathy D. McCoy, Andrew J. MacPherson, and Didier Trono.
PubMed - Fulltext

Cold Spring Harb Perspect Biol. 2017 Apr 21. pii: a029363. doi: 10.1101/cshperspect.a029363. [Epub ahead of print]
Do the Microbiota Influence Protective Immunity to Pathogens? Can this Be Exploited to Improve Vaccine Efficacy?
Macpherson AJ.
PubMed - Fulltext

Gut Microbes. 2017 Mar 1:1-7. doi: 10.1080/19490976.2017.1299847. [Epub ahead of print]
Maternal microbiota and antibodies as advocates of neonatal health.
Ganal-Vonarburg SC, Fuhrer T, Gomez de Agüero M.
PubMed - Fulltext

2016

Cell Host Microbe. 2016 Nov 9;20(5):561-571. doi: 10.1016/j.chom.2016.10.016. Review.
The Liver at the Nexus of Host-Microbial Interactions.
Macpherson AJ, Heikenwalder M, Ganal-Vonarburg SC.
PubMed - Fulltext - PDF Reprint (OPEN ACCESS)

Genome Announc. 2016 Sep 15;4(5). pii: e00951-16. doi: 10.1128/genomeA.00951-16.
Complete Genome Sequences of 12 Species of Stable Defined Moderately Diverse Mouse Microbiota 2.
Uchimura Y, Wyss M, Brugiroux S, Limenitakis JP, Stecher B, McCoy KD, Macpherson AJ.
PubMed - Fulltext - PDF (OPEN ACCESS)

Nat Microbiol. 2016 Nov 21;2:16215. doi: 10.1038/nmicrobiol.2016.215.
Genome-guided design of a defined mouse microbiota that confers colonization resistance against Salmonella enterica serovar Typhimurium.
Brugiroux S, Beutler M, Pfann C, Garzetti D, Ruscheweyh HJ, Ring D, Diehl M, Herp S, Lötscher Y, Hussain S, Bunk B, Pukall R, Huson DH, Münch PC, McHardy AC, McCoy KD, Macpherson AJ, Loy A, Clavel T, Berry D, Stecher B.
PubMed - Fulltext

Nat Protoc. 2016 Aug;11(8):1531-53. doi: 10.1038/nprot.2016.091.
Analysis of bacterial-surface-specific antibodies in body fluids using bacterial flow cytometry.
Moor K, Fadlallah J, Toska A, Sterlin D, Balmer ML, Macpherson AJ, Gorochov G, Larsen M, Slack E.
PubMed - Fulltext

Trends Mol Med. 2016 Sep;22(9):739-41. doi: 10.1016/j.molmed.2016.06.010.
Our Mothers' Antibodies as Guardians of our Commensals.
Ganal-Vonarburg SC, Macpherson AJ.
PubMed - Fulltext - PDF Reprint (OPEN ACCESS)

Immunity. 2016 Jun 21;44(6):1312-24. doi: 10.1016/j.immuni.2016.03.016.
Memory CD8(+) T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function.
Balmer ML, Ma EH, Bantug GR, Grählert J, Pfister S, Glatter T, Jauch A, Dimeloe S, Slack E, Dehio P, Krzyzaniak MA, King CG, Burgener AV, Fischer M, Develioglu L, Belle R, Recher M, Bonilla WV, Macpherson AJ, Hapfelmeier S, Jones RG, Hess C.
PubMed - Fulltext

Science. 2016 Mar 18;351(6279):1296-302.
The maternal microbiota drives early postnatal innate immune development.
Gomez de Agüero M, Ganal-Vonarburg SC, Fuhrer T, Rupp S, Uchimura Y, Li H, Steinert A, Heikenwalder M, Hapfelmeier S, Sauer U, McCoy KD, and Macpherson AJ.
PubMed - Abstract - PDF Reprint (OPEN ACCESS) - Fulltext

 

2015

Immunity. 2015 Nov 17;43(5):998-1010.
The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation.
Zaiss MM, Rapin A, Lebon L, Dubey LK, Mosconi I, Sarter K, Piersigilli A, Menin L, Walker AW, Rougemont J, Paerewijck O, Geldhof P, McCoy KD, Macpherson AJ, Croese J, Giacomin PR, Loukas A, Junt T, Marsland BJ, Harris NL.
PubMed - PDF (OPEN ACCESS)

Nat Commun. 2015 Sep 22;6:8292.
The outer mucus layer hosts a distinct intestinal microbial niche.
Li H, Limenitakis JP, Fuhrer T, Geuking MB, Lawson MA, Wyss M, Brugiroux S, Keller I, Macpherson JA, Rupp S, Stolp B, Stein JV, Stecher B, Sauer U, McCoy KD, and Macpherson AJ.
PubMed - PDF (OPEN ACCESS)

Mucosal Immunol. 2015 Sep 16.
CD4 T cells are required for both development and maintenance of disease in a new mouse model of reversible colitis.
Brasseit J, Althaus-Steiner E, Faderl M, Dickgreber N, Saurer L, Genitsch V, Dolowschiak T, Li H, Finke D, Hardt WD, McCoy KD, Macpherson AJ, Corazza N, Noti M, Mueller C.
PubMed - PDF (Password)

Immunity. 2015 Sep 15;43(3):416-8.
Independence Day for IgA.
Macpherson AJ, McCoy KD.
PubMed - PDF (Password)

Trends Immunol. 2015 Aug;36(8):460-70.
The bilateral responsiveness between intestinal microbes and IgA.
Macpherson AJ, Köller Y, McCoy KD.
PubMed - PDF (Password)

J Clin Invest. 2015 Jul 1;125(7):2579-91.
IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms.
Mager LF, Riether C, Schürch CM, Banz Y, Wasmer MH, Stuber R, Theocharides AP, Li X, Xia Y, Saito H, Nakae S, Baerlocher GM, Manz MG, McCoy KD, Macpherson AJ, Ochsenbein AF, Beutler B, Krebs P.
PubMed - PDF (Password)

Hepatology. 2015 May;61(5):1685-95.
Attenuated portal hypertension in germ-free mice: Function of bacterial flora on the development of mesenteric lymphatic and blood vessels.
Moghadamrad S, McCoy KD, Geuking MB, Sägesser H, Kirundi J, Macpherson AJ, De Gottardi A.
PubMed - PDF (Password)

Clin Immunol. 2015 May 16. pii: S1521-6616(15)00169-2.
New developments providing mechanistic insight into the impact of the microbiota on allergic disease.
McCoy KD and Köller Y.
PubMed - PDF (Password)

Mucosal Immunol. 2015 May;8(3):476-486.
Standardised animal models of host microbial mutualism.
Andrew J Macpherson & Kathy D McCoy
PubMed - PDF (OPEN ACCESS)

J Immunol. 2015 Apr 15;194(8):3723-34.
Deficiency of MALT1 Paracaspase Activity Results in Unbalanced Regulatory and Effector T and B Cell Responses Leading to Multiorgan Inflammation.
Bornancin F, Renner F, Touil R, Sic H, Kolb Y, Touil-Allaoui I, Rush JS, Smith PA, Bigaud M, Junker-Walker U, Burkhart C, Dawson J, Niwa S, Katopodis A, Nuesslein-Hildesheim B, Weckbecker G, Zenke G, Kinzel B, Traggiai E, Brenner D, Brüstle A, St Paul M, Zamurovic N, McCoy KD, Rolink A, Régnier CH, Mak TW, Ohashi PS, Patel DD, Calzascia T.
PubMed - PDF (Password)

EMBO Rep. 2015 Feb;16(2):127-9.
Penetrability of the inner mucus layer: who is out there?
Li H, Limenitakis JP, Ganal SC, Macpherson AJ.
PubMed - PDF (Password)

Inflamm Bowel Dis. 2015 Jan;21(1):60-70.
Factors associated with durable response to infliximab in Crohn's disease 5 years and beyond: a multicenter international cohort.
Juillerat P, Sokol H, Froehlich F, Yajnik V, Beaugerie L, Lucci M, Burnand B, Macpherson AJ, Cosnes J, Korzenik JR.
PubMed - PDF (Password)

Hepatology. 2015 Jan 16. doi: 10.1002/hep.27698.
Attenuated portal hypertension in germ-free mice: Function of bacterial flora on the development of mesenteric lymphatic and blood vessels.
Moghadamrad S, McCoy KD, Geuking MB, Sägesser H, Kirundi J, Macpherson AJ, De Gottardi A.
PubMed - PDF (Password)
 

2014

Immunity. 2014 Nov 20;41(5):789-801.
ATP-gated ionotropic P2X7 receptor controls follicular T helper cell numbers in Peyer's patches to promote host-microbiota mutualism.
Proietti M, Cornacchione V, Rezzonico Jost T, Romagnani A, Faliti CE, Perruzza L, Rigoni R, Radaelli E, Caprioli F, Preziuso S, Brannetti B, Thelen M, McCoy KD, Slack E, Traggiai E, Grassi F.
PubMed - PDF (Password)

J Immunol. 2014 Nov 15;193(10):5273-83.
Microbiota-derived compounds drive steady-state granulopoesis via MyD88/TICAM signaling.
Balmer ML, Schürch CM, Saito, Y, Geuking MB, Hai Li, Ceunca M, Kovtonyuk, LV, McCoy KD, Hapfelmeier S, Ochsenbein AF, Manz MG, Slack E, Macpherson AJ.
PubMed - PDF (Password)

Elife. 2014 Sep 2;3:e04246.
An ambulance for retinol.
Ganal SC and Macpherson AJ.
PubMed - PDF (Password)

PNAS 2014 ; published ahead of print August 25, 2014.
Commensal bacteria protect against food allergen sensitization.
Andrew T. Stefka, Taylor Feehley, Prabhanshu Tripathi, Ju Qiu, Kathy McCoy, Sarkis K. Mazmanian, Melissa Y. Tjota, Goo-Young Seo, Severine Cao, Betty R. Theriault, Dionysios A. Antonopoulos, Liang Zhou, Eugene B. Chang, Yang-Xin Fu, and Cathryn R. Nagler.
PubMed - PDF (Password)

J Exp Med. 2014 Jul 28;211(8):1657-72.
Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo.
Chu DK, Jimenez-Saiz R, Verschoor CP, Walker TD, Goncharova S, Llop-Guevara A, Shen P, Gordon ME, Barra NG, Bassett JD, Kong J, Fattouh R, McCoy KD, Bowdish DM, Erjefält JS, Pabst O, Humbles AA, Kolbeck R, Waserman S, Jordana M.
PubMed - PDF (Password)

Immunol Rev. 2014 Jul;260(1):50-66.
B cells as a critical node in the microbiota-host immune system network.
Slack E, Balmer ML, Macpherson AJ.
PubMed - PDF (Password)

Gut Microbes. 2014 Jun 12;5(3).
The interplay between the gut microbiota and the immune system.
Markus Geuking, Yasmin Köller, Sandra Rupp, and Kathy D. McCoy
PubMed - PDF (OPEN ACCESS)

Immunity. 2014 Apr 17;40(4):608-20.
Segmented filamentous bacterium uses secondary and tertiary lymphoid tissues to induce gut IgA and specific T helper 17 cell responses.
Lécuyer E, Rakotobe S, Lengliné-Garnier H, Lebreton C, Picard M, Juste C, Fritzen R, Eberl G, McCoy KD, Macpherson AJ, Reynaud CA, Cerf-Bensussan N, Gaboriau-Routhiau V
PubMed - PDF

Sci Transl Med 6, 237ra66 (2014).
The Liver May Act as a Firewall Mediating Mutualism Between the Host and Its Gut Commensal Microbiota.
Maria L. Balmer, Emma Slack, Andrea de Gottardi, Melissa A. E. Lawson, Siegfried Hapfelmeier, Luca Miele, Antonio Grieco, Hans Van Vlierberghe, René Fahrner, Nicola Patuto, Christine Bernsmeier, Francesca Ronchi, Madeleine Wyss, Deborah Stroka, Nina Dickgreber, Markus H. Heim, McCoy KD, and Macpherson AJ.
Abstract - PDF (OPEN ACCESS) - HTML Fulltext (OPEN ACCESS)

2013

Semin Immunol. 2013 Nov 12. pii: S1044-5323(13)00078-X. doi: 10.1016/j.smim.2013.09.004.
Stratification and compartmentalisation of immunoglobulin responses to commensal intestinal microbes.
Andrew Macpherson and Kathy D. McCoy
PubMed - PDF (password)

Cell Host & Microbes 14, 559–570, November 13, 2013
Intestinal Microbial Diversity during Early-Life Colonization Shapes Long-Term IgE Levels
Julia Cahenzli, Yasmin Köller, Madeleine Wyss, Markus B. Geuking, and Kathy D. McCoy
PubMed - PDF (OPEN ACCESS) - PMC (OPEN ACCESS)

Journal of Hepatology 2013 Jan;60(1):197-209. doi: 10.1016/j.jhep.2013.07.044.
Pathological bacterial translocation in liver cirrhosis.
Wiest R., Lawson M, and Geuking MB.
PubMed - PDF (password)

Cell Research (2013):1-2.
Metabolites  from  intestinal  microbes  shape  Treg .
Geuking MB, McCoy KD, Macpherson AJ.
PubMed - PDF (password)

Mucosal Immunol. 2013 Mar 20.
Intestinal bacteria induce TSLP to promote mutualistic T-cell responses.
Mosconi I, Geuking MB, Zaiss MM, Massacand JC, Aschwanden C, Kwong Chung CK, McCoy KD, Harris NL.
PubMed - PDF (OPEN ACCESS)

Science. 2013 Jan 17.
Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity.
Markle JG, Frank DN, Mortin-Toth S, Robertson CE, Feazel LM, Rolle-Kampczyk U, von Bergen M, McCoy KD, Macpherson AJ, Danska JS.
PubMed - PDF (password)

Immunology. 2013 Jan;138(1):12-22.
Microbial-immune cross-talk and regulation of the immune system.
Cahenzli J, Balmer ML, McCoy KD.
PubMed - PDF (OPEN ACCESS) - PMC (OPEN ACCESS)

2012

Inflamm Bowel Dis. 2012 Aug;18(8):1434-46. doi: 10.1002/ibd.22848.
Commensal and probiotic bacteria influence intestinal barrier function and susceptibility to colitis in Nod1-/-; Nod2-/- mice.
Natividad JM, Petit V, Huang X, de Palma G, Jury J, Sanz Y, Philpott D, Garcia Rodenas CL, McCoy KD, Verdu EF.
PubMed - PDF (password)

Science. 2012 Jun 8;336(6086):1268-73. doi: 10.1126/science.1223490.
Interactions between the microbiota and the immune system.
Hooper LV, Littman DR, Macpherson AJ.
PubMed - PDF (password)

PLoS One. 2012;7(4):e36009. doi: 10.1371/journal.pone.0036009.
Generation and analysis of a mouse intestinal metatranscriptome through Illumina based RNA-sequencing.
Xiong X, Frank DN, Robertson CE, Hung SS, Markle J, Canty AJ, McCoy KD, Macpherson AJ, Poussier P, Danska JS, Parkinson J.
PubMed - PDF (password)

Trends Immunol. 2012 Apr;33(4):160-7. doi: 10.1016/j.it.2012.02.002.
Homeland security: IgA immunity at the frontiers of the body.
Macpherson AJ, Geuking MB, McCoy KD.
PubMed - PDF (password)

J Exp Med. 2012 Feb 13;209(2):365-77. doi: 10.1084/jem.20111980.
Age, microbiota, and T cells shape diverse individual IgA repertoires in the intestine.
Lindner C, Wahl B, Föhse L, Suerbaum S, Macpherson AJ, Prinz I, Pabst O.
PubMed - PDF (password)

Semin Immunol. 2012 Feb;24(1):36-42. doi: 10.1016/j.smim.2011.11.005.
The function of secretory IgA in the context of the intestinal continuum of adaptive immune responses in host-microbial mutualism.
Geuking MB, McCoy KD, Macpherson AJ.
PubMed - PDF (password)

Front Biosci (Schol Ed). 2012 Jan 1;4:685-98.
Innate and adaptive immunity in host-microbiota mutualism.
Macpherson AJ, Geuking MB, McCoy KD.
PubMed - PDF (password)

Immunol Rev. 2012 Jan;245(1):132-46. doi: 10.1111/j.1600-065X.2011.01072.x.
The habitat, double life, citizenship, and forgetfulness of IgA.
Macpherson AJ, Geuking MB, Slack E, Hapfelmeier S, McCoy KD.
PubMed - PDF (password)

2011

Nature. 2011 Dec 11;481(7380):199-203. doi: 10.1038/nature10698.
Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut.
Fritz JH, Rojas OL, Simard N, McCarthy DD, Hapfelmeier S, Rubino S, Robertson SJ, Larijani M, Gosselin J, Ivanov II, Martin A, Casellas R, Philpott DJ, Girardin SE, McCoy KD, Macpherson AJ, Paige CJ, Gommerman JL.
PubMed - PDF (password)

J Hepatol. 2011 Dec;55(6):1181-3. doi: 10.1016/j.jhep.2011.05.003.
Evaluation of the gut barrier to intestinal bacteria in non-alcoholic fatty liver disease.
De Gottardi A, McCoy KD.
PubMed - PDF (password)

Gut Microbes. 2011 Nov-Dec;2(6):353-7. doi: 10.4161/gmic.18604.
The continuum of intestinal CD4+ T cell adaptations in host-microbial mutualism.
Geuking MB, McCoy KD, Macpherson AJ.
PubMed - PDF (password) - PDF (OPEN ACCESS)

Gut. 2011 Nov;60(11):1506-19. doi: 10.1136/gut.2010.224774.
Systemic antibody responses to gut commensal bacteria during chronic HIV-1 infection.
Haas A, Zimmermann K, Graw F, Slack E, Rusert P, Ledergerber B, Bossart W, Weber R, Thurnheer MC, Battegay M, Hirschel B, Vernazza P, Patuto N, Macpherson AJ, Günthard HF, Oxenius A; Swiss HIV Cohort Study.
PubMed - PDF (password)

Nat Med. 2011 Nov 20;17(12):1585-93. doi: 10.1038/nm.2505.
Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut.
Shulzhenko N, Morgun A, Hsiao W, Battle M, Yao M, Gavrilova O, Orandle M, Mayer L, Macpherson AJ, McCoy KD, Fraser-Liggett C, Matzinger P.
PubMed - PDF (password)

Curr Opin Gastroenterol. 2011 Oct;27(6):529-33. doi: 10.1097/MOG.0b013e32834bb805.
Immunoglobulin A: a bridge between innate and adaptive immunity.
Macpherson AJ, Geuking MB, McCoy KD.
PubMed - PDF (password)

Ann N Y Acad Sci. 2011 Oct;1236:17-29. doi: 10.1111/j.1749-6632.2011.06251.x.
Wild immunology: converging on the real world.
Babayan SA, Allen JE, Bradley JE, Geuking MB, Graham AL, Grencis RK, Kaufman J, McCoy KD, Paterson S, Smith KG, Turnbaugh PJ, Viney ME, Maizels RM, Pedersen AB.
PubMed - PDF (password)

J Immunol. 2011 Oct 15;187(8):4338-46. doi: 10.4049/jimmunol.1100854.
Sensitization to gliadin induces moderate enteropathy and insulitis in nonobese diabetic-DQ8 mice.
Galipeau HJ, Rulli NE, Jury J, Huang X, Araya R, Murray JA, David CS, Chirdo FG, McCoy KD, Verdu EF.
PubMed - PDF (password)

J Clin Invest. 2011 Oct;121(10):3991-4002. doi: 10.1172/JCI45563. Erratum in: J Clin Invest. 2012 Feb 1;122(2):778.
Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy.
McCarthy DD, Kujawa J, Wilson C, Papandile A, Poreci U, Porfilio EA, Ward L, Lawson MA, Macpherson AJ, McCoy KD, Pei Y, Novak L, Lee JY, Julian BA, Novak J, Ranger A, Gommerman JL, Browning JL.
PubMed - PDF (password)

Ther Umsch. 2011 Aug;68(8):459-62. doi: 10.1024/0040-5930/a000194.
[Abdominal pain - differential diagnoses and diagnostic strategies in patients with chronic symptoms].
Güller U, Macpherson AJ.
PubMed

Gastroenterology. 2011 Aug;141(2):599-609, 609.e1-3. doi: 10.1053/j.gastro.2011.04.052.
The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice.
Bercik P, Denou E, Collins J, Jackson W, Lu J, Jury J, Deng Y, Blennerhassett P, Macri J, McCoy KD, Verdu EF, Collins SM.
PubMed - PDF (password)

Am J Physiol Gastrointest Liver Physiol. 2011 Jul;301(1):G188-93. doi: 10.1152/ajpgi.00105.2011.
Eukaryotic and prokaryotic contributions to colonic hydrogen sulfide synthesis.
Flannigan KL, McCoy KD, Wallace JL.
PubMed - PDF (password)

Immunity. 2011 May 27;34(5):794-806. doi: 10.1016/j.immuni.2011.03.021.
Intestinal bacterial colonization induces mutualistic regulatory T cell responses.
Geuking MB, Cahenzli J, Lawson MA, Ng DC, Slack E, Hapfelmeier S, McCoy KD, Macpherson AJ.
PubMed - PDF (password)

PLoS One. 2011 Mar 21;6(3):e17996. doi: 10.1371/journal.pone.0017996.
Depletion of murine intestinal microbiota: effects on gut mucosa and epithelial gene expression.
Reikvam DH, Erofeev A, Sandvik A, Grcic V, Jahnsen FL, Gaustad P, McCoy KD, Macpherson AJ, Meza-Zepeda LA, Johansen FE.
PubMed - PDF (password)

2010

Commun Integr Biol. 2010 Nov;3(6):569-71. doi: 10.4161/cib.3.6.13011.
In remembrance of commensal intestinal microbes.
Hapfelmeier S, Macpherson AJ.
PubMed - PDF (password)

PLoS Pathog. 2010 Sep 9;6(9):e1001097. doi: 10.1371/journal.ppat.1001097.
The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal Salmonella diarrhea.
Endt K, Stecher B, Chaffron S, Slack E, Tchitchek N, Benecke A, Van Maele L, Sirard JC, Mueller AJ, Heikenwalder M, Macpherson AJ, Strugnell R, von Mering C, Hardt WD.
PubMed - PDF (password)

Science. 2010 Jun 25;328(5986):1705-9. doi: 10.1126/science.1188454.
Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses.
Hapfelmeier S, Lawson MA, Slack E, Kirundi JK, Stoel M, Heikenwalder M, Cahenzli J, Velykoredko Y, Balmer ML, Endt K, Geuking MB, Curtiss R 3rd, McCoy KD, Macpherson AJ.
PubMed - PDF (password)

Nat Rev Immunol. 2010 Mar;10(3):159-69. doi: 10.1038/nri2710.
Immune adaptations that maintain homeostasis with the intestinal microbiota.
Hooper LV, Macpherson AJ.
PubMed - PDF (password)

PLoS Pathog. 2010 Jan;6(1):e1000711. doi: 10.1371/journal.ppat.1000711.
Like will to like: abundances of closely related species can predict susceptibility to intestinal colonization by pathogenic and commensal bacteria.
Stecher B, Chaffron S, Käppeli R, Hapfelmeier S, Freedrich S, Weber TC, Kirundi J, Suar M, McCoy KD, von Mering C, Macpherson AJ, Hardt WD.
PubMed - PDF (password)

2009

Semin Immunopathol. 2009 Jul;31(2):145-9. doi: 10.1007/s00281-009-0174-3.
The mucosal firewalls against commensal intestinal microbes.
Macpherson AJ, Slack E, Geuking MB, McCoy KD.
PubMed - PDF (password)

PLoS One. 2009 Jul 31;4(7):e6472. doi: 10.1371/journal.pone.0006472.
Host responses to intestinal microbial antigens in gluten-sensitive mice.
Natividad JM, Huang X, Slack E, Jury J, Sanz Y, David C, Denou E, Yang P, Murray J, McCoy KD, Verdú EF.
PubMed - PDF (password)

Science. 2009 Jul 31;325(5940):617-20. doi: 10.1126/science.1172747.
Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism.
Slack E, Hapfelmeier S, Stecher B, Velykoredko Y, Stoel M, Lawson MA, Geuking MB, Beutler B, Tedder TF, Hardt WD, Bercik P, Verdu EF, McCoy KD, Macpherson AJ.
PubMed - PDF (password)

Eur J Immunol. 2009 Jun;39(6):1505-15. doi: 10.1002/eji.200839019.
Antigens expressed by myelinating glia cells induce peripheral cross-tolerance of endogenous CD8+ T cells.
Schildknecht A, Probst HC, McCoy KD, Miescher I, Brenner C, Leone DP, Suter U, Ohashi PS, van den Broek M.
PubMed - PDF (password)

J Infect Dis. 2009 Jan 15;199(2):243-52. doi: 10.1086/595791.
Bacterial colitis increases susceptibility to oral prion disease.
Sigurdson CJ, Heikenwalder M, Manco G, Barthel M, Schwarz P, Stecher B, Krautler NJ, Hardt WD, Seifert B, MacPherson AJ, Corthesy I, Aguzzi A.
PubMed - PDF (password)

2008

Cell Host Microbe. 2008 Oct 16;4(4):362-73. doi: 10.1016/j.chom.2008.08.014.
Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection.
McCoy KD, Stoel M, Stettler R, Merky P, Fink K, Senn BM, Schaer C, Massacand J, Odermatt B, Oettgen HC, Zinkernagel RM, Bos NA, Hengartner H, Macpherson AJ, Harris NL.
PubMed - PDF (password)

Am J Pathol. 2008 Jun;172(6):1555-70. doi: 10.2353/ajpath.2008.070572.
Overexpression of lymphotoxin in T cells induces fulminant thymic involution.
Heikenwalder M, Prinz M, Zeller N, Lang KS, Junt T, Rossi S, Tumanov A, Schmidt H, Priller J, Flatz L, Rülicke T, Macpherson AJ, Holländer GA, Nedospasov SA, Aguzzi A.
PubMed - PDF (password)

Eur J Immunol. 2008 Jan;38(1):90-101.
Long-term maternal imprinting of the specific B cell repertoire by maternal antibodies.
Fink K, Zellweger R, Weber J, Manjarrez-Orduno N, Holdener M, Senn BM, Hengartner H, Zinkernagel RM, Macpherson AJ.
PubMed - PDF (password)

Mucosal Immunol. 2008 Jan;1(1):11-22. doi: 10.1038/mi.2007.6.
The immune geography of IgA induction and function.
Macpherson AJ, McCoy KD, Johansen FE, Brandtzaeg P.
PubMed - PDF (password)

2007

Curr Opin Gastroenterol. 2007 Nov;23(6):673-8.
The functional interactions of commensal bacteria with intestinal secretory IgA.
Macpherson AJ, Slack E.
PubMed - PDF (password)

PLoS Biol. 2007 Oct;5(10):2177-89.
Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota.
Stecher B, Robbiani R, Walker AW, Westendorf AM, Barthel M, Kremer M, Chaffron S, Macpherson AJ, Buer J, Parkhill J, Dougan G, von Mering C, Hardt WD.
PubMed - PDF (password)

Immunity. 2007 Jun;26(6):755-7.
APRIL in the intestine: a good destination for immunoglobulin A(2).
Macpherson AJ, McCoy K.
PubMed - PDF (password)

Eur J Immunol. 2007 May;37(5):1275-84.
Identification and characterization of a novel antigen from the nematode Nippostrongylus brasiliensis recognized by specific IgE.
Pochanke V, Koller S, Dayer R, Hatak S, Ludewig B, Zinkernagel RM, Hengartner H, McCoy KD.
PubMed - PDF (password)

Semin Immunol. 2007 Apr;19(2):57-8.
The armed truce between the intestinal microflora and host mucosal immunity.
Macpherson AJ, Hapfelmeier S, McCoy KD.
PubMed - PDF (password)

Semin Immunol. 2007 Apr;19(2):59-69. Epub 2006 Nov 21.
Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota.
Smith K, McCoy KD, Macpherson AJ.
PubMed - PDF (password)

2006

J Immunol. 2006 Nov 15;177(10):6824-32.
Adaptation of solitary intestinal lymphoid tissue in response to microbiota and chemokine receptor CCR7 signaling.
Pabst O, Herbrand H, Friedrichsen M, Velaga S, Dorsch M, Berhardt G, Worbs T, Macpherson AJ, Förster R.
PubMed - PDF (password)

J Immunol. 2006 Nov 1;177(9):6256-62.
Mechanisms of neonatal mucosal antibody protection.
Harris NL, Spoerri I, Schopfer JF, Nembrini C, Merky P, Massacand J, Urban JF Jr, Lamarre A, Burki K, Odermatt B, Zinkernagel RM, Macpherson AJ.
PubMed - PDF (password)

Curr Top Microbiol Immunol. 2006;308:117-36.
IgA adaptation to the presence of commensal bacteria in the intestine.
Macpherson AJ.

PubMed - PDF (password)

Eur J Immunol. 2006 Sep;36(9):2434-45.
Induction of IgE and allergic-type responses in fur mite-infested mice.
Pochanke V, Hatak S, Hengartner H, Zinkernagel RM, McCoy KD.
PubMed - PDF (password)

J Exp Med. 2006 Aug 7;203(8):2033-42.
Nonneutralizing antibodies binding to the surface glycoprotein of lymphocytic choriomeningitis virus reduce early virus spread.
Hangartner L, Zellweger RM, Giobbi M, Weber J, Eschli B, McCoy KD, Harris N, Recher M, Zinkernagel RM, Hengartner H.
PubMed - PDF (password)

Immunity. 2006 Mar;24(3):329-39.
Natural IgE production in the absence of MHC Class II cognate help.
McCoy KD, Harris NL, Diener P, Hatak S, Odermatt B, Hangartner L, Senn BM, Marsland BJ, Geuking MB, Hengartner H, Macpherson AJ, Zinkernagel RM.
PubMed - PDF (password)

J Exp Med. 2006 Mar 20;203(3):497-500.
Mesenteric lymph nodes at the center of immune anatomy.
Macpherson AJ, Smith K.
PubMed - PDF (password)

Gut. 2006 Feb;55(2):276-84.
Layers of mutualism with commensal bacteria protect us from intestinal inflammation.
Mueller C, Macpherson AJ.
PubMed - PDF (password)

2005

Nature Immunology 2005 March;Volume 6 Number 3:280-86.
Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4.
Probst HC, McCoy KD, Okazaki T, Honjo T, and van den Broek M.
PubMed - PDF (password)

Infect Immun. 2005 Jun;73(6):3228-41.
Comparison of Salmonella enterica serovar Typhimurium colitis in germfree mice and mice pretreated with streptomycin.
Stecher B, Macpherson AJ, Hapfelmeier S, Kremer M, Stallmach T, Hardt WD.
PubMed - PDF (password)

Immunology. 2005 Jun;115(2):153-62.
Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria.
Macpherson AJ, Geuking MB, McCoy KD.
PubMed - PDF (password)

2004

Ann N Y Acad Sci. 2004 Dec;1029:36-43.
Compartmentalization of the mucosal immune responses to commensal intestinal bacteria.
Macpherson AJ
, Uhr T.
PubMed - PDF (password)

Nat Rev Immunol. 2004 Jun;4(6):478-85.
Interactions between commensal intestinal bacteria and the immune system.
Macpherson AJ
, Harris NL.
PubMed - PDF (password)

Eur J Immunol. 2004 Apr;34(4):1041-9.
Role of TCR-restricting MHC density and thymic environment on selection and survival of cells expressing low-affinity T cell receptors.
Martinic MM, Rocha B, McCoy KD, Hengartner H, Zinkernagel RM.
PubMed - PDF (password)

Science. 2004 Mar 12;303(5664):1662-5.
Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria.
Macpherson AJ,
Uhr T.
PubMed - PDF (password)

2003

Eur J Immunogenet. 2003 Jun;30(3):187-90.
Genetic variation in the IGSF6 gene and lack of association with inflammatory bowel disease.
King K, Moody A, Fisher SA, Mirza MM, Cuthbert AP, Hampe J, Sutherland-Craggs A, Sanderson J, MacPherson AJ, Forbes A, Mansfield J, Schreiber S, Lewis CM, Mathew CG.
PubMed - PDF (password)

Am J Pathol. 2003 Apr;162(4):1103-11.
Oral prion infection requires normal numbers of Peyer's patches but not of enteric lymphocytes.
Prinz M, Huber G, Macpherson AJ, Heppner FL, Glatzel M, Eugster HP, Wagner N, Aguzzi A.
PubMed - PDF (password)

Nat Immunol. 2003 Apr;4(4):343-9.
Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections.
Hunziker L, Recher M, Macpherson AJ, Ciurea A, Freigang S, Hengartner H, Zinkernagel RM.
PubMed - PDF (password)

Am J Hum Genet. 2003 Apr;72(4):1018-22.
Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn disease.
Mirza MM, Fisher SA, King K, Cuthbert AP, Hampe J, Sanderson J, Mansfield J, Donaldson P, Macpherson AJ, Forbes A, Schreiber S, Lewis CM, Mathew CG.
PubMed - PDF (password)

Immunogenetics. 2003 Jan;54(10):693-8.
The donor splice site mutation in NFkappaB-inducing kinase of alymphoplasia (aly/aly) mice.
Macpherson AJ
, Uhr T.
PubMed - PDF (password)

2002

Cell Mol Life Sci. 2002 Dec;59(12):2088-96.
The functions of mucosal T cells in containing the indigenous commensal flora of the intestine.
Macpherson AJ
, Martinic MM, Harris N.
PubMed - PDF (password)

Eur J Surg Suppl. 2002;(587):53-7.
Gut flora--mechanisms of regulation.
Macpherson AJ
, Uhr T.
PubMed

Nat Immunol. 2002 Sep;3(9):798-800.
BLySsful interactions between DCs and B cells.
Macpherson AJ
, Lamarre A.
PubMed - PDF (password)

Gut. 2002 Jul;51(1):21-5.
In siblings with similar genetic susceptibility for inflammatory bowel disease, smokers tend to develop Crohn's disease and non-smokers develop ulcerative colitis.
Bridger S, Lee JC, Bjarnason I, Jones JE, Macpherson AJ.
PubMed - PDF (password)

Eur J Hum Genet. 2002 Apr;10(4):259-65.
Sex stratification of an inflammatory bowel disease genome search shows male-specific linkage to the HLA region of chromosome 6.
Fisher SA, Hampe J, Macpherson AJ, Forbes A, Lennard-Jones JE, Schreiber S, Curran ME, Mathew CG, Lewis CM.
PubMed - PDF (password)

2001

Microbes Infect. 2001 Oct;3(12):1021-35.
IgA responses in the intestinal mucosa against pathogenic and non-pathogenic microorganisms.
Macpherson AJ, Hunziker L, McCoy K, Lamarre A.
PubMed - PDF (password)

Nat Immunol. 2001 Jul;2(7):625-31.
IgA production without mu or delta chain expression in developing B cells.
Macpherson AJ, Lamarre A, McCoy K, Harriman GR, Odermatt B, Dougan G, Hengartner H, Zinkernagel RM.
PubMed - PDF (password)

Lancet. 2001 Jun 16;357(9272):1925-8. Erratum in: Lancet 2002 Sep 7;360(9335):806.
Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations.
Hampe J, Cuthbert A, Croucher PJ, Mirza MM, Mascheretti S, Fisher S, Frenzel H, King K, Hasselmeyer A, MacPherson AJ, Bridger S, van Deventer S, Forbes A, Nikolaus S, Lennard-Jones JE, Foelsch UR, Krawczak M, Lewis C, Schreiber S, Mathew CG.
PubMed - PDF (password)

Adv Immunol. 2001;79:1-53.
Neutralizing antiviral antibody responses.
Zinkernagel RM, LaMarre A, Ciurea A, Hunziker L, Ochsenbein AF, McCoy KD, Fehr T, Bachmann MF, Kalinke U, Hengartner H.
PubMed - PDF (password)

J Immunol. 2001 Mar 15;166(6):3678-87.
Rapid peptide turnover and inefficient presentation of exogenous antigen critically limit the activation of self-reactive CTL by dendritic cells.
Ludewig B, McCoy K, Pericin M, Ochsenbein AF, Dumrese T, Odermatt B, Toes RE, Melief CJ, Hengartner H, Zinkernagel RM.
PubMed - PDF (password)

Gut. 2001 Feb;48(2):191-7.
Fine mapping of the chromosome 3p susceptibility locus in inflammatory bowel disease.
Hampe J, Lynch NJ, Daniels S, Bridger S, Macpherson AJ, Stokkers P, Forbes A, Lennard-Jones JE, Mathew CG, Curran ME, Schreiber S.
PubMed - PDF (password)

2000

Eur J Immunol. 2000 Jul;30(7):1929-38.
T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis.
Senn KA, McCoy KD, Maloy KJ, Stark G, Fröhli E, Rülicke T, Klemenz R.
PubMed - PDF (password)

Science. 2000 Jun 23;288(5474):2222-6.
A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria.
Macpherson AJ, Gatto D, Sainsbury E, Harriman GR, Hengartner H, Zinkernagel RM.
PubMed - PDF (password)

Infect Immun. 2000 May;68(5):2976-8.
Role of Eosinophils in the Pathogenesis of Mycobacterium bovis BCG Infection in Gamma Interferon Receptor-Deficient Mice.
Kirman J, Zakaria Z, McCoy K, Delahunt B, Le Gros G.
PubMed - PDF (password)

Immunogenetics. 2000 Jan;51(1):1-7.
Analysis of single-nucleotide polymorphisms in the interleukin-4 receptor gene for association with inflammatory bowel disease.
Olavesen MG, Hampe J, Mirza MM, Saiz R, Lewis CM, Bridger S, Teare D, Easton DF, Herrmann T, Scott G, Hirst J, Sanderson J, Hodgson SV, Lee J, MacPherson A, Schreiber S, Lennard-Jones JE, Curran ME, Mathew CG.
PubMed - PDF (password)

1999

Am J Hum Genet. 1999 Dec;65(6):1647-55.
Linkage of inflammatory bowel disease to human chromosome 6p.
Hampe J, Shaw SH, Saiz R, Leysens N, Lantermann A, Mascheretti S, Lynch NJ, MacPherson AJ, Bridger S, van Deventer S, Stokkers P, Morin P, Mirza MM, Forbes A, Lennard-Jones JE, Mathew CG, Curran ME, Schreiber S.
PubMed - PDF (password)

Gut. 1999 Jun;44(6):808-11.
Why children with inflammatory bowel disease are diagnosed at a younger age than their affected parent.
Lee JC, Bridger S, McGregor C, Macpherson AJ, Jones JE.
PubMed - PDF (password)

Infect Immun. 1999 Aug;67(8):3786-92.
CTLA-4 Blockade Enhances the Immune Response Induced by Mycobacterial Infection but Does Not Lead to Increased Protection.
Kirman J, McCoy K, Hook S, Prout M, Delahunt B, Orme I, Frank A, Le Gros G.
PubMed - PDF (password)

Gut. 1999 Jun;44(6):774-5.
Intolerance of the dirty intestine.
Macpherson AJ
, Maloy KJ, Bjarnason I.
PubMed - PDF (password)

J Exp Med. 1999 Apr 5;189(7):1157-62.
Cytotoxic T lymphocyte-associated antigen (CTLA-4) can regulate dendritic cell-induced activation and cytotoxicity of CD8(+) T cells independently of CD4(+) T cell help.
McCoy KD, Hermans IF, Fraser JH, Le Gros G, Ronchese F.
PubMed - PDF (password)

Am J Hum Genet. 1999 Mar;64(3):808-16.
A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort.
Hampe J, Schreiber S, Shaw SH, Lau KF, Bridger S, Macpherson AJ, Cardon LR, Sakul H, Harris TJ, Buckler A, Hall J, Stokkers P, van Deventer SJ, Nürnberg P, Mirza MM, Lee JC, Lennard-Jones JE, Mathew CG, Curran ME.
PubMed - PDF (password)

Eur J Immunol. 1999 Mar;29(3):838-44.
CTLA4 ligation attenuates AP-1, NFAT and MF-kappaB activity in activated T cells.
Fraser JH, Rincón M, McCoy KD, Le Gros G.
PubMed - PDF (password)

Immunol Cell Biol. 1999 Feb;77(1):1-10.
The role of CTLA-4 in the regulation of T cell immune responses.
McCoy KD, Le Gros G.
PubMed - PDF (password)

1998

Int J Colorectal Dis. 1998;13(5-6):260-3.
The interferon-gamma gene as a positional and functional candidate gene for inflammatory bowel disease.
Hampe J, Hermann B, Bridger S, MacPherson AJ, Mathew CG, Schreiber S.
PubMed - PDF (password)

Gastroenterology. 1998 Nov;115(5):1066-71.
Genetic analysis of inflammatory bowel disease in a large European cohort supports linkage to chromosomes 12 and 16.
Curran ME, Lau KF, Hampe J, Schreiber S, Bridger S, Macpherson AJ, Cardon LR, Sakul H, Harris TJ, Stokkers P, Van Deventer SJ, Mirza M, Raedler A, Kruis W, Meckler U, Theuer D, Herrmann T, Gionchetti P, Lee J, Mathew C, Lennard-Jones J.
PubMed - PDF (password)

Gut. 1998 Oct;43(4):506-11.
Intestinal permeability and inflammation in patients on NSAIDs.
Sigthorsson G, Tibble J, Hayllar J, Menzies I, Macpherson A, Moots R, Scott D, Gumpel MJ, Bjarnason I.
PubMed - PDF (passwrod)

1997

J Exp Med. 1997 Jul 21;186(2):183-7.
Protective immunity to nematode infection is induced by CTLA-4 blockade.
McCoy KD, Camberis M, Le Gros G.
PubMed - PDF (password)

J Biol Chem. 1997 Jul 11;272(28):17276-82.
The hemopoietic growth factor, interleukin-3, promotes glucose transport by increasing the specific activity and maintaining the affinity for glucose of plasma membrane glucose transporters.
McCoy KD, Ahmed N, Tan AS, Berridge MV.
PubMed - PDF (password)

J Immunol. 1997 Apr 15;158(8):3626-34.
CD4+ T cell down-regulation in human intestinal mucosa: evidence for intestinal tolerance to luminal bacterial antigens.
Khoo UY, Proctor IE, Macpherson AJ.
PubMed - PDF (password)

Gut. 1997 Feb;40(2):228-33.
Reduced bone density in patients with inflammatory bowel disease.
Bjarnason I, Macpherson A, Mackintosh C, Buxton-Thomas M, Forgacs I, Moniz C.
PubMed - PDF (password)

Scand J Gastroenterol. 1997 Feb;32(2):126-30.
A randomized, double-blind, crossover comparative endoscopy study on the gastroduodenal tolerability of a highly specific cyclooxygenase-2 inhibitor, flosulide, and naproxen.
Bjarnason I, Macpherson A, Rotman H, Schupp J, Hayllar J.
PubMed

before 1997

AIDS. 1996 Oct;10(12):1385-91.
Intestinal inflammation, ileal structure and function in HIV.
Bjarnason, I., Sharpstone, D.R., Francis, N., Marker, A., Taylor, C., Barrett, M., Macpherson AJ, Baldwin, C., Menzies, I.S., Crane, R.C., Smith, T., Pozniak, A., Gazzard, B.G.
PubMed

Gut. 1996 Sep;39(3):374-81.
Evaluation of differential disaccharide excretion in urine for non- invasive investigation of altered intestinal disaccharidase activity caused by alpha-glucosidase inhibition, primary hypolactasia, and coeliac disease.
Bjarnason, I., Batt, R., Catt, S., Macpherson AJ, Maxton, D. & Menzies, I. S.
PubMed - PDF (password)

Gut. 1996 Aug;39(2):338-9.
Pouch permeability: breaching barriers to understanding pouchitis?
Bjarnason, I., Menzies, I. & Macpherson AJ
PubMed - PDF (password)

J Immunol. 1996 Jun 1;156(11):4092-9.
CD95 (Fas/apo-1)-induced apoptosis results in loss of glucose transporter function.
Berridge MV, Tan AS, McCoy KD, Kansara M, Rudert F.
PubMed - PDF (password)

Lancet. 1995 Dec 23-30;346 Suppl:s6.
Gastroenterology. Basic science 1, clinical gastroenterology 0.
Macpherson AJ
, Bjarnason I.
PubMed

Biochem J. 1995 Jun 1;308 ( Pt 2):665-71.
Mitochondrial gene expression in small intestinal epithelial cells.
Mayall TP, Bjarnason I, Khoo UY, Peters TJ, Macpherson AJ.
PubMed - PDF (password)

Gastroenterology. 1995 May;108(5):1566-81.
Intestinal permeability: an overview.
Bjarnason, I., Macpherson AJ and Hollander, D.
PubMed - PDF (password)

Scand J Gastroenterol. 1995 Apr;30(4):289-99.
The biochemical basis of non-steroidal anti-inflammatory drug-induced damage to the gastrointestinal tract: a review and a hypothesis.
Somasundaram S, Hayllar H, Rafi S, Wrigglesworth JM, Macpherson AJ, Bjarnason I.
PubMed

Lancet. 1994 Oct 1;344(8927):903-4.
Colonocytes in Barrett's metaplasia?
Macpherson AJ
, Bjarnason I.
PubMed

Pharmacol Ther. 1994 Apr-May;62(1-2):145-57.
Intestinal toxicity of non-steroidal anti-inflammatory drugs.
Bjarnason I, Macpherson AJ.
PubMed

Gastroenterology. 1994 Feb;106(2):318-23.
The effect of intestinal hypoperfusion on intestinal absorption and permeability during cardiopulmonary bypass.
Ohri, S., Somasundaram, S., Macpherson AJ, Keogh, B.E., Taylor, K.M., Menzies, I., Bjarnason, I.
PubMed

Lancet. 1994 Jan 15;343(8890):130-1.
Inflammatory bowel disease of mice--and men?
Macpherson AJ
, Khoo UY, Bjarnason I.
PubMed

Gastroenterology. 1993 Jun;104(6):1832-47.
Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans.
Bjarnason I, Hayllar J, MacPherson AJ, Russell AS.
PubMed

J Pathol. 1992 Dec;168(4):405-11.
Localization of CEA messenger RNA by in situ hybridization in normal colonic mucosa and colorectal adenocarcinomas.
Abbasi AM, Chester KA, MacPherson AJ, Boxer GM, Begent RH, Malcolm AD.
PubMed

J Cell Sci. 1992 Jun;102 ( Pt 2):307-14.
Mitochondrial gene expression in the human gastrointestinal tract.
Macpherson AJ
, Mayall TP, Chester KA, Abbasi A, Forgacs I, Malcolm AD, Peters TJ.
PubMed - PDF (password)

Gut. 1992 May;33(5):651-6.
Increased expression of c-myc proto-oncogene in biopsies of ulcerative colitis and Crohn's colitis.
Macpherson AJ
, Chester KA, Robson L, Bjarnason I, Malcolm AD, Peters TJ.
PubMed - PDF (password)

Gastroenterology. 1992 May;102(5):1546-50.
Glucose and citrate reduce the permeability changes caused by indomethacin in humans.
Bjarnson, I. , Smethurst, P., Macpherson A., McElvin, E., Parsons, P. and Menzies, I.S.
PubMed

BMJ. 1992 Apr 4;304(6831):858-9.
Discovery of the gene for familial adenomatous polyposis.
Macpherson AJ
, Bjarnason I, Forgacs IC.
PubMed - PDF (password)

Clin Sci (Lond). 1992 Jan;82(1):71-6.
Increased energy expenditure in cystic fibrosis is associated with specific mutations.
O'Rawe A, McIntosh I, Dodge JA, Brock DJ, Redmond AO, Ward R, Macpherson AJ.
PubMed

Alcohol Alcohol. 1991;26(4):399-402.
The 'topping-up' effect: differences between low- and non-alcoholic lager on blood ethanol.
Ward RJ, Macpherson AJ, Peek G, Bailey ME, Peters TJ.
PubMed

J Pathol. 1990 Dec;162(4):309-15.
In situ and slot hybridization analysis of RNA in colorectal tumours and normal colon shows distinct distributions of mitochondrial sequences.
Chester KA, Robson L, Begent RH, Pringle H, Primrose L, Talbot IC, Macpherson AJ, Owen SL, Boxer G, Malcolm AD.
PubMed

Drug Alcohol Depend. 1990 Aug;26(1):1-8.
Ethanol-induced smooth and skeletal muscle myopathy: use of animal studies.
Preedy VR, Marway JS, Macpherson AJ, Peters TJ.
PubMed

Biochim Biophys Acta. 1989 Dec 22;1009(3):297-300.
Identification of a human ribosomal protein mRNA with increased expression in colorectal tumours.
Chester KA, Robson L, Begent RH, Talbot IC, Pringle JH, Primrose L, Macpherson AJ, Boxer G, Southall P, Malcolm AD.
PubMed

Nucleic Acids Res. 1989 Sep 25;17(18):7549.
A PvuII RFLP in the human ADH2 gene.
Shah T, Macpherson AJ, Ward RJ, Peters TJ, Yoshida A.
PubMed - PDF (password)

Clin Exp Dermatol. 1989 Jul;14(4):304-5.
Treatment of dermatomyositis associated with carcinoma by plasmapheresis.
Macpherson A, Berth-Jones J, Graham-Brown RA.
PubMed

Clin Chim Acta. 1986 Sep 15;159(2):133-8.
The subcellular distribution and levels of calmodulin in jejunal biopsies from control subjects and patients with coeliac disease.
Macpherson AJ
, Bjarnason I, Peters TJ.
PubMed

Methods Enzymol. 1986;125:387-429.
Assay, genetics, proteins, and reconstitution of proton-linked galactose, arabinose, and xylose transport systems of Escherichia coli.
Henderson PJ, Macpherson AJ.
PubMed

Biochem Soc Trans. 1984 Apr;12(2):146-8.
Sugar-proton transport systems of Escherichia coli.
Henderson PJ, Bradley S, Macpherson AJ, Horne P, Davis EO, Daruwalla KR, Jones-Mortimer MC.
PubMed

J Biol Chem. 1983 Apr 10;258(7):4390-6.
Identification of the GalP galactose transport protein of Escherichia coli.
Macpherson AJ, Jones-Mortimer MC, Horne P, Henderson PJ.
PubMed - PDF (password)

Biochem J. 1981 Apr 15;196(1):269-83.
Identification of the AraE transport protein of Escherichia coli.
MacPherson AJ, Jones-Mortimer MC, Henderson PJ.
PubMed - PDF (password)

Biochem J. 1980 Mar 15;186(3):749-54.
Requirement for guanosine triphosphate for cholera-toxin-catalysed incorporation of adenosine diphosphate ribose into rat liver plasma membranes and for activation of adenylate cyclase.
Doberska CA, MacPherson AJ, Martin BR.
PubMed - PDF (password)

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