Journal Club 2012

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Ciclosporin versus infliximab in colitis ulcerosa:

  • Laharie D. et al.: Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial. Lancet. 2012 Oct 9. pii: S0140-6736(12)61084-8.


Proton pump inhibitor and SIBO

Celiac disease and pancreatitis


Infections and mortality in Crohn`s disease:

Lichtenstein et al.: Serious infections and mortality in association with therapies for Crohn's disease: TREAT registry. Clin Gastroenterol Hepatol. 2006 May;4(5):621-30.

IBS symptoms in IBD:

  • Halpin SJ et al. Prevalence of symptoms meeting criteria for irritable bowel syndrome in inflammatory bowel disease: systematic review and meta-analysis.Am J Gastroenterol. 2012 Oct;107(10):1474-82.


Eltrombopag before procedures in cirrhosis:

Short course Terlipressin in acute variceal bleeding:


Tofacitinib in active Ulcerative Colitis

BMI and colorectal adenomas:

Okabayashi K et al.: Body mass index category as a risk factor for colorectal adenomas: a systematic review and meta-analysis. Am J Gastroenterol. 2012 Aug;107(8):1175-85.


Expandable stents for malignant esophageal disease

Neoadjuvant chemoradiotherapy for esophageal or junctional cancer:


Safety of long-term infliximab treatment, with/without concomitant immunomodulators

  • Lichtenstein et al.: A pooled analysis of infections, malignancy, and mortality in infliximab- and immunomodulator-treated adult patients with inflammatory bowel disease. Am J Gastroenterol. 2012 Jul;107(7):1051-63.

Fecal micobiota transplant for recurrent clostridium difficile infection:

  • Brandt et al.: Long-term follow-up of colonoscopic fecal microbiota transplant for recurrent clostridium difficile infection. Am J Gastroenterol. 2012 Jul;107(7):1079-87.


Diet in therapy of eosinophilic esophagitis

  • Gonsalves et al.: Elimination diet effectively treats eosinophilic esophagitis in adults; food reintroduction identifies causative factors. Gastroenterology. 2012;142(7):1451-1459.

Rifaximin in patients with crohn disease

Prantera et al.: Rifaximin-extended intestinal release induces remission in patients with
moderately active crohn’s disease. Gastroenterology 2012;142:473–481.


Outcome of pregnant IBD patients treated with thiopurines:

Risk factors for endoscopic removal of colorectal tumors:

  • Meining et. al.: Risk factors for unfavorable outcomes after endoscopic removal of submucosal invasive colorectal tumors. Clinical gastroenterology and hepatology 2011;9:590–594.


Bariatric surgery and type 2 Diabetes in obese patients:


Risk for relatives of patients with serrated adenoma:

Cox-2-inhibitors and H. pylori eradication in precancerous gastric lesions:


Thiopurines for prevention of colorectal neoplasia in IBD:

Indeomethacin to prevent post-ERCP pancreatitis


Clinical details  superior to oesophageal pH-impedance to predict PPI response:

  • Zerbib et al.: Clinical, but not oesophageal pH-impedance, profiles predict response to proton pump inhibitors in gastro-oesophageal reflux disease. Gut 2012 Apr;61(4):501-6.

Fourthline therapy after three times eradication failure in H. pylori infection:

  • Gisbert et al.: Fourth-line rescue therapy with rifabutin in patients with three Helicobacter pylori eradication failures. Aliment. Pharmacol. Ther 2012 Apr;35(8):941-7


Budesonide in treating lymphocytic colitis:

Ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease:


Peroral endoscopic myotomy in achalasia

Abdominal breath exercise in gastroesophageal reflux disease:

Eherer et al: Positive Effect of Abdominal Breathing Exercise on Gastroesophageal Reflux Disease: A Randomized, Controlled Study. Am J Gastroenterol 2012; 107:372–378


Colonoscopy versus fecal imunochemical testing in colorectal-cancer screening

Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths:

Rate and predictors of early/missed colorectal cancers after colonoscopy:

Association between colonoscopy rates and colorectal cancer mortality:


Tobacco smoking as risk factor of high-grade dysplasia and cancer in Barrett’s esophagus:


NSAIDs and statins as chemoprevention in Barrett's esophagus:

Kastellein et al.: Nonsteroidal anti-inflammatory drugs and statins have chemopreventative effects in patients with Barrett's esophagus.Gastroenterology. 2011;141:2000-8.

in vitro gliadin challenge in difficult to diagnose celiac disease


The role of erythromycin in acute upper gastrointestinal hemorrhage

TFAP2E–DKK4 and Chemoresistance in Colorectal Cancer


Propofol vs Midazolam in sub-clinical hepatic encephalopathy:

Khamaysi et al.: Sub-clinical hepatic encephalopathy in cirrhotic patients is not aggravated by sedation with propofol compared to midazolam: A randomized controlled study. J Hepatol 2011;54:72–77.

Long-term effect of Aspirin on CRC in Lynch Syndrome:

Burn et al.: Long-term eff ect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet 2011;378:2081–87.


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