Journal Club Archive

Journal Club 2016

Friday, Nov. 19th, 2016 - Jakob Zimmermann

Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

Monday, Nov. 14th, 2016 - Catherine Mooser

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer's Patch T Follicular Helper Cells

Friday, Nov. 11th, 2016 - Marcel Sorribas

FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis

Obeticholic acid reduces bacterial translocation and inhibits intestinal inflammation in cirrhotic rats

Monday, Nov. 7th, 2016 - Francesca Ronchi

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome

Stable Engraftment of Bifidobacterium longum AH1206 in the Human Gut Depends on Individualized Features of the Resident Microbiome

Monday, Oct. 31st, 2016 - Miguelangel Cuenca

Nutrient Deprivation Affects Salmonella Invasion and Its Interaction with the Gastrointestinal Microbiota

Antivirulence activity of the human gut metabolome

Friday, Oct. 21st, 2016 - Nicolas Studer

The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia

Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection

Monday, Sep. 26th, 2016 - Stefanie Buschor

Virulence factors enhance Citrobacter rodentium expansion through aerobic respiration

Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells

Friday, Sep. 16th, 2016 - Stephanie Ganal-Vonarburg

The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome

Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice

Friday, Sep. 12th, 2016 - Julien Limenitakis

Transcriptional interactions suggest niche segregation among microorganisms in the human gut.

Interplay between microbial D-amino acids and host D-amino acid oxidase modifies murine mucosal defence and gut microbiota

Friday, Sep. 5th, 2016 - Hai Li

Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome

High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in mice

Friday, Aug. 22nd, 2016 - Bahti YILMAZ

Gut Microbial Metabolites Fuel Host Antibody Responses

Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut

Friday, Aug. 15th, 2016 - Stephanie Uster

Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism

Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site

Friday, July 8th, 2016 - Mercedes Gomez

Mouse and Human Liver Contain Immunoglobulin A-Secreting Cells Originating From Peyer's Patches and Directed Against Intestinal Antigens

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

Friday, June 17th, 2016 - Francesca Ronchi

Normalizing the environment recapitulates adult human immune traits in laboratory mice

Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation

Friday, June 2nd, 2016 - Li Hai

Defensive Mutualism Rescues NADPH Oxidase Inactivation in Gut Infection

Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice

Friday, May 27th, 2016 - Catherine Mooser

Defensive Mutualism Rescues NADPH Oxidase Inactivation in Gut Infection

IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches

Friday, May 20th, 2016 - Bahti Yilmaz

Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life

Friday, April 29th, 2016 - Marcel Sorribas

Changes in gut toll-like receptor-4 and nod-like receptor family pyrin domain containing-3 innate pathways in liver cirrhosis rats with bacterial translocation

Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation

Friday, April 22nd, 2016 - Stephanie Ganal

Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella

Enteric Viruses Ameliorate Gut Inflammation via Toll-like Receptor 3 and Toll-like Receptor 7-Mediated Interferon-β Production

Friday, date to be announced, 2016 - Yasu Uchimura

Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages

Design and synthesis of a minimal bacterial genome.

Genetic circuit design automation

Friday, April 8th, 2016 - Julien Limenitakis

Carriage of λ Latent Virus Is Costly for Its Bacterial Host due to Frequent Reactivation in Monoxenic Mouse Intestine

Host Selection of Microbiota via Differential Adhesion

Friday, March 18th, 2016 - Mercedes Gomez

Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells

Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer

Friday, March 11th, 2016 - Li Hai

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens

Friday, February 26th, 2016 - Yasmin Köller

Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition

Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children

Friday, February 19th, 2016 - Sandra Rupp

The maternal interleukin-17a pathway in mice promotes autismlike phenotypes in offspring

Long-lived plasma cells are generated in mucosal immune responses and contribute to the bone marrow plasma cell pool in mice

Friday, February 12th, 2016 - Francesca Ronchi

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut

Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine

Friday, January 29th, 2016 - Catherine Mooser

Diet-induced extinctions in the gut microbiota compound over generations

Microbiota depletion promotes browning of white adipose tissue and reduces obesity

Friday, January 8th, 2016 - Stephanie Ganal

Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

Journal Club 2015

Monday, Dec. 14th, 2015 - Marcel

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

Friday, Dec. 11th, 2015 - Madeleine

Regulators of gut motility revealed by a gnotobiotic model of diet-microbiome interactions related to travel

Early life dynamics of the human gut virome and bacterial microbiome in infants

Friday, Dec. 4th, 2015 - Bahti

Personalized Nutrition by Prediction of Glycemic Responses

Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment

Friday, Nov. 27th, 2015 - Yasu

Single-cell messenger RNA sequencing reveals rare intestinal cell types

Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis

Friday, Nov. 20th, 2015 - Mercedes

Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

Monday, Nov. 16th, 2015 - Anna

MHC variation sculpts individualized microbial communities that control susceptibility to enteric infection

BALB/c and C57BL/6 Mice Differ in Polyreactive IgA Abundance, which Impacts the Generation of Antigen-Specific IgA and Microbiota Diversity

Friday, October 30th, 2015 - Li Hai

Bacteriocin production augments niche competition by enterococci in the mammalian gastrointestinal tract

Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment

Friday, October 16th, 2015 - Francesca

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection

Friday, October 9th, 2015 - Sandra

Genetic determinants of in vivo fitness and diet responsiveness in multiple human gut Bacteroides

Early infancy microbial and metabolic alterations affect risk of childhood asthma

Friday, September 25th, 2015 - Yasmin

Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

Friday, September 11th, 2015 - Catherine

In vivo imaging and tracking of host-microbiota interactions via metabolic labeling of gut anaerobic bacteria

Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model

Friday, August 28th, 2015 - Marcel

Pathogenic NLRP3 Inflammasome Activity during Candida Infection Is Negatively Regulated by IL-22 via Activation of NLRC4 and IL-1Ra

Pancreatic β-Cells Limit Autoimmune Diabetes via an Immunoregulatory Antimicrobial Peptide Expressed under the Influence of the Gut Microbiota

Friday, August 21st, 2015 - Stephanie

Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 Responses

MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of RORγ⁺ regulatory T cells

Friday, August 14th, 2015 - Yasu

A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses

Metabolism links bacterial biofilms and colon carcinogenesis

Friday, August 7th, 2015 - Medeleine

MyD88 Adaptor-Dependent Microbial Sensing by Regulatory T Cells Promotes Mucosal Tolerance and Enforces Commensalism

Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis

Friday, July 24th, 2015 - Anna

Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17

The microbiota regulates type 2 immunity through RORγt+ T cells

Friday, July 10th, 2015 - Mercedes

Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota.

Retinoic Acid Differentially Regulates the Migration of Innate Lymphoid Cell Subsets to the Gut

Friday, July 3rd, 2015 - Julien

Extensive strain-level copy-number variation across human gut microbiome species

Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment

Friday, June 26th, 2015 - Li Hai

Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma

Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization

Friday, June 19th, 2015 - Yasmin

Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2-Dependent Regulation of the Microbiota

Innate immunity. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity

Friday, June 12th, 2015 - Catherine and Sandra

The bamboo-eating giant panda harbors a carnivore-like gut microbiota, with excessive seasonal variations

Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation

Friday, June 5th, 2015 - Catherine

Humoral Immunity in the Gut Selectively Targets Phenotypically Virulent Attaching-and-Effacing Bacteria for Intraluminal Elimination

Friday, May 29th, 2015 - Francesca

Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism.

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

Friday, May 22nd, 2015 - Stephi and Anna

Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury

Friday, May 15th, 2015 - Marcel

Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status

Colonic MUC2 mucin regulates the expression and antimicrobial activity of β-defensin 2

Friday, May 8th, 2015 - Madeleine

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

Friday, May 1st, 2015 - Anna

Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury

Friday, April 17th, 2015 - Yasu

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

The gut commensal bacteroides thetaiotaomicron exacerbates enteric infection through modification of the metabolic landscape

Friday, April 10th, 2015 - Julien

Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota

Improving microbial fitness in the mammalian gut by in vivo temporal functional metagenomics

Friday, March 27th, 2015 - Li Hai

Biogeography of the intestinal mucosal and lumenal microbiome in the rhesus macaque

Friday, March 13th, 2015 - Mercedes

Identification of natural RORγ ligands that regulate the development of lymphoid cells

Analysis of gene-environment interactions in postnatal development of the mammalian intestine

Friday, March 6th, 2015 - Francesca

The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome

Friday, Feb. 6th, 2015 - Stephanie

Gut microbiota. Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation

MyD88 Signaling in T Cells Directs IgA-Mediated Control of the Microbiota to Promote Health.

Friday, Jan. 30th, 2015 - Yasmin

Growth and host interaction of mouse segmented filamentous bacteria in vitro

IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production

Friday, Jan. 23rd, 2015 - Catherine

Diet dominates host genotype in shaping the murine gut microbiota

Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism

Friday, Jan. 9th, 2015 - Yasu

Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects

Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine

Journal Club 2014

Friday, Dec. 19th, 2014 - Sandra

Gut Microbiota Elicits a Protective Immune Response against Malaria Transmission

Staphylococcus aureus infection induces protein A-mediated immune evasion in humans

Friday, Dec. 12th, 2014 - Anna

Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell-dependent inflammation

The Chemokine Receptor CXCR6 Controls the Functional Topography of Interleukin-22 Producing Intestinal Innate Lymphoid Cells

Friday, Nov. 28th, 2014 - William

An enteric virus can replace the beneficial function of commensal bacteria

Interleukin-22 Regulates the Complement System to Promote Resistance against Pathobionts after Pathogen-Induced Intestinal Damage

Friday, Nov. 21st, 2014 - Mercedes

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

Regulatory B cells are induced by gut microbiota-driven interleukin-1β and interleukin-6 production

Friday, Nov. 10th, 2014 - Julien

Human genetics shape the gut microbiome

Rapid changes in the gut microbiome during human evolution

Friday, Nov. 6th, 2014 - Li Hai

Homeostatic IL-23 receptor signaling limits Th17 response through IL-22-mediated containment of commensal microbiota

Dietary modulation of the microbiome affects autoinflammatory disease

Friday, October 31st, 2014 - Stephanie

MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion

Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis

Friday, October 24th, 2014 - Anna

Bacteria from diverse habitats colonize and compete in the mouse gut

Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium

Friday, October 17th, 2014 - Yasmin

Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness

Epithelial IL-22RA1-Mediated Fucosylation Promotes Intestinal Colonization Resistance to an Opportunistic Pathogen

Friday, October 10th, 2014 - Yasu

Members of the human gut microbiota involved in recovery from Vibrio cholerae infection

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

Friday, October 3rd, 2014 - Francesca

Artificial sweeteners induce glucose intolerance by altering the gut microbiota

A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells

Friday, September 26th, 2014 - Catherine

TLR5-Mediated Sensing of Gut Microbiota Is Necessary for Antibody Responses to Seasonal Influenza Vaccination

Immunoglobulin a coating identifies colitogenic bacteria in inflammatory bowel disease

​​​​Friday, September 12th, 2014 - Sandra

B cell homeostasis and follicle confines are governed by fibroblastic reticular cells

CD4+ T Cells and CD40 Participate in Selection and Homeostasis of Peripheral B Cells

Friday, September 5th, 2014 - William

High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4

​​Friday, August 29th, 2014 - Mercedes Gomez

CX3CR1+ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22

Science. 2014 Aug, AOP DOI: 10.1126/science.1254009 Innate lymphoid cells regulate intestinal epithelial cell glycosylation

Friday, August 22nd, 2014 - Julien

Phenotypic variation of salmonella in host tissues delays eradication by antimicrobial chemotherapy

Inactivation of a single gene enables microaerobic growth of the obligate anaerobe Bacteroides fragilis

Friday, August 15th, 2014 - Li Hai

Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

A type VI secretion-related pathway in Bacteroidetes mediates interbacterial antagonism

Friday, August 8th, 2014 - Stephanie

The alarmin IL-33 promotes regulatory T-cell function in the intestine

Bacterial Sensor Nod2 Prevents Inflammation of the Small Intestine by Restricting the Expansion of the Commensal Bacteroides vulgatus

Friday, July 25th, 2014 - Yasmin

Immunoglobulin E Signal Inhibition during Allergen Ingestion Leads to Reversal of Established Food Allergy and Induction of Regulatory T Cells

Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility

Friday, July 18th, 2014 - Yasu and Sandra

TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells

Aryl hydrocarbon receptor control of a disease tolerance defence pathway

Friday, July 11th, 2014 - Francesca Ronchi

Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis

Unique lamina propria stromal cells imprint the functional phenotype of mucosal dendritic cells

Friday, July 4th, 2014 - Anna Steinert

Oral tolerance can be established via gap junction transfer of fed antigens from CX3CR1+ macrophages to CD103+ dendritic cells

Differentiation of CD11c+ CX3CR1+ cells in the small intestine requires Notch signaling

​​Friday, June 20th, 2014 - Sandra Rupp

Clonal selection in the germinal centre by regulated proliferation and hypermutation

CD4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus

​Friday, June 13th, 2014 - William Kwong Chung

Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis

Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

Friday, June 6th, 2014 - Julien Limenitakis

Relating the metatranscriptome and metagenome of the human gut

Human gut microbes use multiple transporters to distinguish vitamin B₁₂ analogs and compete in the gut

Friday, May 30th, 2014 - Li Hai

Dynamics and associations of microbial community types across the human body

Segmented filamentous bacterium uses secondary and tertiary lymphoid tissues to induce gut IgA and specific T helper 17 cell responses

Friday, May 9th, 2014 - Mercedes

Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice

Friday, May 2nd, 2014 - Yasmin

Eosinophils are required for the maintenance of plasma cells in the bone marrow

Eosinophils promote generation and maintenance of immunoglobulin-a-expressing plasma cells and contribute to gut immune homeostasis

Friday, April 25th, 2014 - Stephanie

A committed precursor to innate lymphoid cells

Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

Friday, April 11th, 2014 - Francesca

Segmented Filamentous Bacteria Antigens Presented by Intestinal Dendritic Cells Drive Mucosal Th17 Cell Differentiation

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion.

Friday, April 4th, 2014 - Anna

Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasisn

Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells

Friday, March 28st, 2014 - Yasu and Sandra

Sulphoglycolysis in Escherichia coli K-12 closes a gap in the biogeochemical sulphur cycle

Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen

Friday, March 21st, 2014 - Julien

The evolution of mutualism in gut microbiota via host epithelial selection

Host-compound foraging by intestinal microbiota revealed by single-cell stable isotope probing

Friday, March 14th, 2014 - William

Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation

Toll-like Receptor and Inflammasome Signals Converge to Amplify the Innate Bactericidal Capacity of T Helper 1 Cells

Friday, March 7th, 2014 - Li Hai

The Cytokine IL-22 Promotes Pathogen Colonization by Suppressing Related Commensal Bacteria

Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression

Friday, February 21st, 2014 - Melissa

Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota

Identifying gut microbe-host phenotype relationships using combinatorial communities in gnotobiotic mice

Friday, February 7th, 2014 - Yasmin

Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity

Gata3 drives development of RORγt+ group 3 innate lymphoid cells

Friday, January 24th, 2014 - Yasu

Gut microbiota from twins discordant for obesity modulate metabolism in mice

Diet rapidly and reproducibly alters the human gut microbiome

Friday, January 10th, 2014 - Mercedes

Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis

TCF-1 controls ILC2 and NKp46+RORγt+ innate lymphocyte differentiation and protection in intestinal inflammation

Journal Club 2013

Friday, December 20th, 2013 - Stephanie Ganal

Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

Friday, December 13th, 2013 - Francesca Ronchi

NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen

Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen

Friday, December 6th, 2013 - Sandra Rupp

A Beneficial Role for Immunoglobulin E in Host Defense against Honeybee Venom

Bee Venom Phospholipase A2 Induces a Primary Type 2 Response that Is Dependent on the Receptor ST2 and Confers Protective Immunity

Friday, Novermber 29th, 2013 - Li Hai

Antibacterial membrane attack by a pore-forming intestinal C-type lectin

Paneth cells as a site of origin for intestinal inflammation

Friday, Novermber 22nd, 2013 - William

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Friday, Novermber 8th, 2013 - Melissa Lawson

Antibiotic treatment expands the resistance reservoir and ecological network of the phage metagenome

Bacterial community mapping of the mouse gastrointestinal tract

Friday, Novermber 1st, 2013 - Yasmin Köller

Type 2 innate lymphoid cells control eosinophil homeostasis

Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection

Friday, October 11th, 2013 - Stephanie Ganal

Extrathymic Aire-Expressing Cells Are a Distinct Bone Marrow-Derived Population that Induce Functional Inactivation of CD4(+) T Cells

Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism

Friday, October 4th, 2013 - Mercedes Gomez

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

Friday, September 27th, 2013 - Francesca Ronchi

Intraluminal Containment of Commensal Outgrowth in the Gut during Infection-Induced Dysbiosis

Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation

Friday, September 20th, 2013 - Sandra Rupp

Microbial colonization influences early B-lineage development in the gut lamina propria

TLR4 Signaling Shapes B Cell Dynamics via MyD88-Dependent Pathways and Rac GTPases

Friday, September 6th, 2013 - Li Hai

Bacterial colonization factors control specificity and stability of the gut microbiota

Friday, August 23rd, 2013 - William Kwong Chung

An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos

BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis

Friday, August 16th, 2013 - Yasuhiro Uchimura

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function

Friday, August 9th, 2013 - Melissa Lawson

Intestinal epithelial autophagy is essential for host defense against invasive bacteria

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

Friday, July 26th, 2013 - Yasmin Köller

Dendritic Cell Expression of the Signaling Molecule TRAF6 Is Critical for Gut Microbiota-Dependent Immune Tolerance

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

Friday, July 19th, 2013 - Thomas Schaffer

T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10

Dysbiosis of the Gut Microbiota Is Associated with HIV Disease Progression and Tryptophan Catabolism

Friday, June 28th, 2013 - Li Hai

IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis

Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation

Friday, June 21st, 2013 - Francesca

Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis

IRF4 Transcription Factor-Dependent CD11b(+) Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses

Friday, June 7th, 2013 - Julia Cahenzli

Role of Tissue Protection in Lethal Respiratory Viral-Bacterial Coinfection

Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection

Friday, May 31th, 2013 - William Kwong

GPR15-Mediated Homing Controls Immune Homeostasis in the Large Intestine Mucosa

Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria

Friday, May 24th, 2013 - Yasu Uchimura

Multidimensional optimality of microbial metabolism

Systematic identification of allosteric protein-metabolite interactions that control enzyme activity in vivo

Friday, May 17th, 2013 - Sandra Rupp

Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells

Cutting edge: macrophages are required for localization of antigen-activated B cells to the follicular perimeter and the subsequent germinal center response

Friday, May 10th, 2013 - Yasmin Köller

Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility

Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells

Friday, May 3rd, 2013 - Melissa Lawson

Tit-for-tat: type VI secretion system counterattack during bacterial cell-cell interaction

Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors

Friday, April 12th, 2013 - Li Hai

Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses

Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity

Friday, April 5th, 2013 - Markus Geuking

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

Friday, March 15th, 2013 - Francesca Ronchi

Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

Friday, February 22th, 2013 - William Kwong Chung

Absence of signaling into CD4(+) cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3(+) regulatory T cells

Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells

Friday, February 15th, 2013 - Yasmin Köller

Host-derived nitrate boosts growth of E. coli in the inflamed gut

TSLP Elicits IL-33-Independent Innate Lymphoid Cell Responses to Promote Skin Inflammatio

Friday, February 8th, 2013 - Sandra Rupp

The Mouse IgM Fc Receptor, FCMR, Promotes B Cell Development and Modulates Antigen-Driven Immune Responses

Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress

Friday, February 1st, 2013 - Mercedes Gomez

Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells

A T-bet gradient controls the fate and function of CCR6(-)RORγt(+) innate lymphoid cells

Friday, January 25th, 2013 - Yasuhiro Uchimura

MR1 presents microbial vitamin B metabolites to MAIT cells

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

Friday, January 18th, 2013 - Li Hai

Antibody orientation at bacterial surfaces is related to invasive infection

Parasite-induced T(H)1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells

Friday, January 11th, 2013 - Melissa Lawson

Fucose sensing regulates bacterial intestinal colonization

The streptomycin-treated mouse intestine selects Escherichia coli envZ missense mutants that interact with dense and diverse intestinal microbiota

Journal Club 2012

Friday, March. 30th, 2012 - Melissa Lawson

Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

Friday, March. 23rd, 2012 - Julia Cahenzli

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage

Friday, March. 9th, 2012 - William Kwong chung

Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells

Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine

Friday, Feb. 12th, 2012 - Mercedes Gomez

Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon

Friday, January 26th, 2012 - Hai Li

Successful transmission of a retrovirus depends on the commensal microbiota

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

Friday, January 19th, 2012 - Melissa Lawson

Innate response activator B cells protect against microbial sepsis

Trade-off between bile resistance and nutritional competence drives Escherichia coli diversification in the mouse gut

Friday, January 13th, 2012 - Julia Cahenzli

B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity

Journal Club 2011

Friday, December. 9th, 2011 - Hai Li

The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

Friday, December. 2nd, 2011 - Markus Geuking

Response to self antigen imprints regulatory memory in tissues

TGF-β induces the expression of the adaptor Ndfip1 to silence IL-4 production during iTreg cell differentiation

Friday, November. 11th, 2011 - Maria Balmer

Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation

Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles

Friday, November. 4th, 2011 - Julia Cahenzli

IL-17C regulates the innate immune function of epithelial cells in an autocrine manner

IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens

Friday, September. 9th, 2011

Identification of an innate T helper type 17 response to intestinal bacterial pathogens

Foxp3+ follicular regulatory T cells control the germinal center response

Friday, April. 28th, 2011

Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation

Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner

Friday, March 4th, 2011 - Markus Geuking

Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria

Fate mapping of IL-17-producing T cells in inflammatory responses