Journal Club 2022

Monday, June. 16th, 2022 - Nerea Fernandez Trigo

Long-term antibiotic exposure promotes mortality after systemic fungal infection by driving lymphocyte dysfunction and systemic escape of commensal bacteria

Cell Host Microbe. 2022 May 7;S1931-3128(22)00219-0. doi: 10.1016/j.chom.2022.04.013.
Rebecca A Drummond, Jigar V Desai, Emily E Ricotta, Muthulekha Swamydas, Clay Deming, Sean Conlan, Mariam Quinones, Veronika Matei-Rascu, Lozan Sherif, David Lecky, Chyi-Chia R Lee, Nathaniel M Green, Nicholas Collins, Adrian M Zelazny, D Rebecca Prevots, David Bending, David Withers, Yasmine Belkaid, Julia A Segre, Michail S Lionakis
PubMed Link​​​​​​​

Friday, Feb. 17th, 2020 - Bahtiyar Yilmaz

A Multihost Bacterial Pathogen Overcomes Continuous Population Bottlenecks to Adapt to New Host Species

Sci Adv, 5 (11), eaax0063 2019 Nov 27 eCollection Nov 2019. DOI: 10.1126/sciadv.aax0063
Rodrigo Bacigalupe, María Ángeles Tormo-Mas, José R Penadés, J Ross Fitzgerald
PubMed Link

Bacterial Adaptation Is Constrained in Complex Communities

Nat Commun, 11 (1), 754 2020 Feb 6. DOI: 10.1038/s41467-020-14570-z
Thomas Scheuerl, Meirion Hopkins, Reuben W Nowell, Damian W Rivett, Timothy G Barraclough, Thomas Bell
PubMed Link

Friday, Feb. 10th, 2020 - Ian Young

Spatial Metagenomic Characterization of Microbial Biogeography in the Gut

Nat Biotechnol, 37 (8), 877-883 Aug 2019. DOI: 10.1038/s41587-019-0183-2
Ravi U Sheth, Mingqiang Li, Weiqian Jiang, Peter A Sims, Kam W Leong, Harris H Wang.
PubMed Link

Sci Immunol, 4 (39) 2019 Sep 27. DOI: 10.1126/sciimmunol.aax4453 Lin28b Controls a Neonatal to Adult Switch in B Cell Positive Selection

Stijn Vanhee, Hugo Åkerstrand, Trine Ahn Kristiansen, Sebak Datta, Giorgia Montano, Stefano Vergani, Stefan Lang, Jonas Ungerbäck, Alexander Doyle, Karin Olsson, Giulia Beneventi, Christina T Jensen, Cristian Bellodi, Shamit Soneji, Mikael Sigvardsson, Elin Jaensson Gyllenbäck, Joan Yuan
PubMed Link

Friday, Jan. 31st, 2020 - Steven Mistzal

Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis

Cell Metab, 31 (1), 115-130.e6 2020 Jan 7
Nupur K Das, Andrew J Schwartz, Gabrielle Barthel, Naohiro Inohara, Qing Liu, Amanda Sankar, David R Hill, Xiaoya Ma, Olivia Lamberg, Matthew K Schnizlein, Juan L Arqués, Jason R Spence, Gabriel Nunez, Andrew D Patterson, Duxin Sun, Vincent B Young, Yatrik M Shah.
PubMed Link

Preventing Dysbiosis of the Neonatal Mouse Intestinal Microbiome Protects Against Late-Onset Sepsis

Nat Med, 25 (11), 1772-1782 Nov 2019. DOI: 10.1038/s41591-019-0640-y
Jeffrey R Singer, Emily G Blosser, Carlene L Zindl, Daniel J Silberger, Sean Conlan, Vincent A Laufer, Daniel DiToro, Clay Deming, Ranjit Kumar, Casey D Morrow, Julia A Segre, Michael J Gray, David A Randolph, Casey T Weaver
PubMed Link

Friday, Jan. 17th, 2020 - Anna Wenning

Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic Versus Commensal Skin Bacteria

Cell Host Microbe, 26 (6), 795-809.e5 2019 Dec 11. DOI: 10.1016/j.chom.2019.10.007
John M Leech, Miqdad O Dhariwala, Margaret M Lowe, Kevin Chu, Geil R Merana, Clémence Cornuot, Antonin Weckel, Jessica M Ma, Elizabeth G Leitner, Jeanmarie R Gonzalez, Kimberly S Vasquez, Binh An Diep, Tiffany C Scharschmidt.
PMID: PubMed Link

Nature, 577 (7791), 543-548 Jan 2020. DOI: 10.1038/s41586-019-1898-4 Microbiota-targeted Maternal Antibodies Protect Neonates From Enteric Infection

Wen Zheng, Wenjing Zhao, Meng Wu, Xinyang Song, Florence Caro, Ximei Sun, Francesca Gazzaniga, Giuseppe Stefanetti, Sungwhan Oh, John J Mekalanos, Dennis L Kasper.
PubMed Link