Prof. Dr. med. Reiner Wiest
Clinical Lead Consultant (Chefarzt)
Oberarzt UVCM Gastroenterologie
- Mechanisms and route of bacterial translocation from the gut in experimental liver cirrhosis
- Sympathetic splanchnic hyperactivity and regulation of intestinal antimicrobial defense’
Attending Gastroenterology UVCM, Gastroenterology, Bern, CH.
Head of Clinical Research and Clinical Trials, Internal Medicine, UR, Germany.
Assistant Professor for Experimental/ Clinical Hepatology, UR, Germany.
Internship and Consultant in Internal Medicine, UR, Germany.
Postdoctoral Research Fellowship, Hepatic Hemodynamic Laboratory Yale University School of Medicine, New Haven, Connecticut, USA.
Investigation of mechanisms responsible for translocation of bacteria and bacterial products from the gut to mesenteric lymph nodes and/or extraintestinal sites in experimental liver cirrhosis. Particular emphasis on the lymphatic route and intestinal dendritic cells, antimicrobial peptides and secretory immunoglobulin A in conjunction with immunological consequences of pathological increases in bacterial translocation. The latter mainly focusing on enhanced antibody secretion, e.g. involving B-cell activation via BAFF known to be increased in liver cirrhosis.